FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2309311162> ?p ?o ?g. }

• W2309311162 endingPage "8146" @default.
• W2309311162 startingPage "8137" @default.
• W2309311162 abstract "Specificity of protein degradation by cellular proteasomes comes from tetra-ubiquitin recognition. We carry out molecular dynamics simulations to characterize how the ubiquitin receptor Rpn10 recognizes in the 26S proteasome K48-linked tetra-ubiquitin. In the binding pose, ubiquitin and Rpn10 interact primarily through hydrophobic patches. However, K48-linked tetra-ubiquitin mostly assumes a closed form in solution prior to binding, in which its hydrophobic patches are not exposed to solvent. Likewise, the hydrophobic ubiquitin interacting motifs (UIMs) of Rpn10 are mostly protected prior to binding. As a result, ubiquitin recognition in the proteasome requires refolding of both K48-linked tetra-ubiquitin and Rpn10. Simulations suggest that conserved complementary electrostatic patterns of Rpn10 and ubiquitins guide protein association (stage 1 in the recognition process), which induces refolding (stage 2), and then facilitates formation of hydrophobic contacts (stage 3). The simulations also explain why Rpn10 has a higher affinity for K48-linked tetra-ubiquitin than for mono-ubiquitin and K48-linked di- and tri-ubiquitins. Simulation results expand on the current view that the flexible arm of Rpn10 acts as an extended fragment of α-helices and flexible coils in the recognition process." @default.
• W2309311162 created "2016-06-24" @default.
• W2309311162 creator A5010814302 @default.
• W2309311162 creator A5015845693 @default.
• W2309311162 creator A5027424609 @default.
• W2309311162 creator A5029996336 @default.
• W2309311162 creator A5044544424 @default.
• W2309311162 date "2016-04-06" @default.
• W2309311162 modified "2023-10-15" @default.
• W2309311162 title "Recognition of Poly-Ubiquitins by the Proteasome through Protein Refolding Guided by Electrostatic and Hydrophobic Interactions" @default.
• W2309311162 cites W1966078827 @default.
• W2309311162 cites W1968991415 @default.
• W2309311162 cites W1972758026 @default.
• W2309311162 cites W1974030600 @default.
• W2309311162 cites W1976499671 @default.
• W2309311162 cites W1994751787 @default.
• W2309311162 cites W2006102455 @default.
• W2309311162 cites W2013339424 @default.
• W2309311162 cites W2016236499 @default.
• W2309311162 cites W2017033636 @default.
• W2309311162 cites W2027408247 @default.
• W2309311162 cites W2029667189 @default.
• W2309311162 cites W2038758364 @default.
• W2309311162 cites W2043416800 @default.
• W2309311162 cites W2045393768 @default.
• W2309311162 cites W2050043175 @default.
• W2309311162 cites W2050333027 @default.
• W2309311162 cites W2056620205 @default.
• W2309311162 cites W2060872117 @default.
• W2309311162 cites W2065283382 @default.
• W2309311162 cites W2067174909 @default.
• W2309311162 cites W2075597028 @default.
• W2309311162 cites W2079449448 @default.
• W2309311162 cites W2084949662 @default.
• W2309311162 cites W2096646435 @default.
• W2309311162 cites W2096929343 @default.
• W2309311162 cites W2097164847 @default.
• W2309311162 cites W2097453957 @default.
• W2309311162 cites W2098370963 @default.
• W2309311162 cites W2106648157 @default.
• W2309311162 cites W2136716105 @default.
• W2309311162 cites W2144062946 @default.
• W2309311162 cites W2150981663 @default.
• W2309311162 cites W2152184357 @default.
• W2309311162 cites W2159923313 @default.
• W2309311162 cites W2171268876 @default.
• W2309311162 cites W2493822791 @default.
• W2309311162 doi "https://doi.org/10.1021/acs.jpcb.6b01327" @default.
• W2309311162 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5001906" @default.
• W2309311162 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27681365" @default.
• W2309311162 hasPublicationYear "2016" @default.
• W2309311162 type Work @default.
• W2309311162 sameAs 2309311162 @default.
• W2309311162 citedByCount "10" @default.
• W2309311162 countsByYear W23093111622016 @default.
• W2309311162 countsByYear W23093111622017 @default.
• W2309311162 countsByYear W23093111622018 @default.
• W2309311162 countsByYear W23093111622019 @default.
• W2309311162 countsByYear W23093111622020 @default.
• W2309311162 countsByYear W23093111622021 @default.
• W2309311162 crossrefType "journal-article" @default.
• W2309311162 hasAuthorship W2309311162A5010814302 @default.
• W2309311162 hasAuthorship W2309311162A5015845693 @default.
• W2309311162 hasAuthorship W2309311162A5027424609 @default.
• W2309311162 hasAuthorship W2309311162A5029996336 @default.
• W2309311162 hasAuthorship W2309311162A5044544424 @default.
• W2309311162 hasBestOaLocation W23093111622 @default.
• W2309311162 hasConcept C104317684 @default.
• W2309311162 hasConcept C12554922 @default.
• W2309311162 hasConcept C134459356 @default.
• W2309311162 hasConcept C185592680 @default.
• W2309311162 hasConcept C25602115 @default.
• W2309311162 hasConcept C27740335 @default.
• W2309311162 hasConcept C2911199164 @default.
• W2309311162 hasConcept C55493867 @default.
• W2309311162 hasConcept C86803240 @default.
• W2309311162 hasConcept C90260826 @default.
• W2309311162 hasConcept C95444343 @default.
• W2309311162 hasConceptScore W2309311162C104317684 @default.
• W2309311162 hasConceptScore W2309311162C12554922 @default.
• W2309311162 hasConceptScore W2309311162C134459356 @default.
• W2309311162 hasConceptScore W2309311162C185592680 @default.
• W2309311162 hasConceptScore W2309311162C25602115 @default.
• W2309311162 hasConceptScore W2309311162C27740335 @default.
• W2309311162 hasConceptScore W2309311162C2911199164 @default.
• W2309311162 hasConceptScore W2309311162C55493867 @default.
• W2309311162 hasConceptScore W2309311162C86803240 @default.
• W2309311162 hasConceptScore W2309311162C90260826 @default.
• W2309311162 hasConceptScore W2309311162C95444343 @default.
• W2309311162 hasFunder F4320321114 @default.
• W2309311162 hasFunder F4320336454 @default.
• W2309311162 hasFunder F4320337354 @default.
• W2309311162 hasIssue "33" @default.
• W2309311162 hasLocation W23093111621 @default.
• W2309311162 hasLocation W23093111622 @default.
• W2309311162 hasLocation W23093111623 @default.
• W2309311162 hasLocation W23093111624 @default.
• W2309311162 hasOpenAccess W2309311162 @default.

• next