Matches in SemOpenAlex for { <https://semopenalex.org/work/W2309341189> ?p ?o ?g. }
- W2309341189 endingPage "14414" @default.
- W2309341189 startingPage "14405" @default.
- W2309341189 abstract "// Qiang Ding 1 , Yujia Xia 1 , Shuping Ding 1 , Panpan Lu 1 , Liang Sun 2 , Mei Liu 1 1 Department of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China 2 Department of Gastroenterology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China Correspondence to: Mei Liu, e-mail: fliumei@126.com Keywords: CXCR3/CXCL9, CD133+ liver cancer cells, metastasis, adhesion Received: October 29, 2015 Accepted: January 28, 2016 Published: February 13, 2016 ABSTRACT Metastasis of liver cancer is closely linked to tumor microenvironment, in which chemokines and their receptors act in an important role. The CXCR3, the receptor of chemokine CXCL9, belongs to a superfamily of rhodopsin-like seven transmembrane GPCRs and CXCR subfamily. In HCC tissues, CXCR3 was frequently upregulated and correlated with tumor size, tumor differentiation, portal invasion and metastasis. In the study, CXCR3-A isoform that was bound by CXCL9 was found to cause significant change of ERK1/2 phosphorylation level in the MAPK signaling pathway, consequently upregulating the MMP2 and MMP9 expression and promoting invasion and metastasis of CD133+ liver cancer cells. Also, CXCR3-A suppressed the adhesion ability of CD133+ liver cancer cells that stimulated by CXCL9 for 24h. These findings suggest that CXCR3 and its ligand CXCL9 could promote the metastasis of liver cancer cells and might be a potential target for the intervention of liver cancer metastasis." @default.
- W2309341189 created "2016-06-24" @default.
- W2309341189 creator A5004356555 @default.
- W2309341189 creator A5025858225 @default.
- W2309341189 creator A5043185825 @default.
- W2309341189 creator A5080147395 @default.
- W2309341189 creator A5084422874 @default.
- W2309341189 creator A5085617980 @default.
- W2309341189 date "2016-02-13" @default.
- W2309341189 modified "2023-10-02" @default.
- W2309341189 title "An alternatively spliced variant of CXCR3 mediates the metastasis of CD133+ liver cancer cells induced by CXCL9" @default.
- W2309341189 cites W1512694675 @default.
- W2309341189 cites W1594725275 @default.
- W2309341189 cites W1657790903 @default.
- W2309341189 cites W1684544176 @default.
- W2309341189 cites W1735416439 @default.
- W2309341189 cites W1920455602 @default.
- W2309341189 cites W1948339188 @default.
- W2309341189 cites W1952389073 @default.
- W2309341189 cites W1965815494 @default.
- W2309341189 cites W1978495907 @default.
- W2309341189 cites W1986531910 @default.
- W2309341189 cites W1990817456 @default.
- W2309341189 cites W1998196052 @default.
- W2309341189 cites W2000778748 @default.
- W2309341189 cites W2003517714 @default.
- W2309341189 cites W2015375238 @default.
- W2309341189 cites W2018444159 @default.
- W2309341189 cites W2023075736 @default.
- W2309341189 cites W2028524759 @default.
- W2309341189 cites W2030917941 @default.
- W2309341189 cites W2033278321 @default.
- W2309341189 cites W2034333033 @default.
- W2309341189 cites W2044228373 @default.
- W2309341189 cites W2044835152 @default.
- W2309341189 cites W2048186014 @default.
- W2309341189 cites W2049937448 @default.
- W2309341189 cites W2052834898 @default.
- W2309341189 cites W2064758832 @default.
- W2309341189 cites W2076865755 @default.
- W2309341189 cites W2089298112 @default.
- W2309341189 cites W2129732298 @default.
- W2309341189 cites W2136638612 @default.
- W2309341189 cites W2158732258 @default.
- W2309341189 cites W2162825929 @default.
- W2309341189 cites W2164710273 @default.
- W2309341189 cites W2213884550 @default.
- W2309341189 cites W2412090798 @default.
- W2309341189 cites W2917837889 @default.
- W2309341189 cites W47082944 @default.
- W2309341189 doi "https://doi.org/10.18632/oncotarget.7360" @default.
- W2309341189 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4924724" @default.
- W2309341189 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26883105" @default.
- W2309341189 hasPublicationYear "2016" @default.
- W2309341189 type Work @default.
- W2309341189 sameAs 2309341189 @default.
- W2309341189 citedByCount "35" @default.
- W2309341189 countsByYear W23093411892016 @default.
- W2309341189 countsByYear W23093411892017 @default.
- W2309341189 countsByYear W23093411892018 @default.
- W2309341189 countsByYear W23093411892019 @default.
- W2309341189 countsByYear W23093411892020 @default.
- W2309341189 countsByYear W23093411892021 @default.
- W2309341189 countsByYear W23093411892022 @default.
- W2309341189 countsByYear W23093411892023 @default.
- W2309341189 crossrefType "journal-article" @default.
- W2309341189 hasAuthorship W2309341189A5004356555 @default.
- W2309341189 hasAuthorship W2309341189A5025858225 @default.
- W2309341189 hasAuthorship W2309341189A5043185825 @default.
- W2309341189 hasAuthorship W2309341189A5080147395 @default.
- W2309341189 hasAuthorship W2309341189A5084422874 @default.
- W2309341189 hasAuthorship W2309341189A5085617980 @default.
- W2309341189 hasBestOaLocation W23093411891 @default.
- W2309341189 hasConcept C121608353 @default.
- W2309341189 hasConcept C126322002 @default.
- W2309341189 hasConcept C12823836 @default.
- W2309341189 hasConcept C13373296 @default.
- W2309341189 hasConcept C170493617 @default.
- W2309341189 hasConcept C17502307 @default.
- W2309341189 hasConcept C203014093 @default.
- W2309341189 hasConcept C25532541 @default.
- W2309341189 hasConcept C2776231280 @default.
- W2309341189 hasConcept C2778019345 @default.
- W2309341189 hasConcept C2779013556 @default.
- W2309341189 hasConcept C2780699576 @default.
- W2309341189 hasConcept C502942594 @default.
- W2309341189 hasConcept C71924100 @default.
- W2309341189 hasConcept C96232424 @default.
- W2309341189 hasConceptScore W2309341189C121608353 @default.
- W2309341189 hasConceptScore W2309341189C126322002 @default.
- W2309341189 hasConceptScore W2309341189C12823836 @default.
- W2309341189 hasConceptScore W2309341189C13373296 @default.
- W2309341189 hasConceptScore W2309341189C170493617 @default.
- W2309341189 hasConceptScore W2309341189C17502307 @default.
- W2309341189 hasConceptScore W2309341189C203014093 @default.
- W2309341189 hasConceptScore W2309341189C25532541 @default.
- W2309341189 hasConceptScore W2309341189C2776231280 @default.
- W2309341189 hasConceptScore W2309341189C2778019345 @default.