FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2309351027> ?p ?o ?g. }

• W2309351027 endingPage "47" @default.
• W2309351027 startingPage "40" @default.
• W2309351027 abstract "Besides neurons, activated microglia and astrocytes in the spinal cord dorsal horn (SCDH) contribute to the pathogenesis of chronic pain. Electroacupuncture (EA) has been used widely to treat various chronic pain diseases, however, the underlying mechanisms of EA are still not fully understood.Male Sprague-Dawley rats were randomly divided into four groups, including an untreated healthy Control group (n=14), a True-spinal nerve ligation (SNL) group that underwent SNL and remained untreated (n=25), a True-SNL+EA group that underwent SNL followed by EA treatment (n=25), and a Sham-SNL group that underwent sham surgery and remained untreated (n=15). SNL was performed unilaterally at L5 and EA was applied to ST36 and BL60 bilaterally once per day. Paw withdrawal thresholds (PWTs) were measured ipsilaterally at baseline and 1, 3, 7, and 14 days after ligation. Activation of microglia and astrocytes in the SCDH were examined bilaterally by immunofluorescence staining, and concentrations of interleukin-1β (IL-1β) and interleukin (IL-6) were measured in the ipsilateral SCDH by ELISA.SNL significantly decreased PWTs and activated glial cells in the superficial laminae of the ipsilateral SCDH. In rats with SNL, glial fibrillary acidic protein (GFAP) immunoreactivity peaked at 7 days and was maintained until 14 days post-ligation, while anti-integrin alphaM (OX-42) immunoreactivity peaked at 3 days and declined gradually. EA significantly alleviated SNL-induced mechanical allodynia. Furthermore, EA reduced microglial activation (OX-42 positive ratios) in the lumbar SCDH at 3 days post-ligation and suppressed astrocyte activation (GFAP positive ratios) at all time points observed.EA stimulation alleviates SNL-induced neuropathic pain, at least in part through inhibition of spinal glial activation. Moreover, inhibition of spinal microglia and astrocyte activation may contribute to the immediate effects and maintenance of EA analgesia, respectively." @default.
• W2309351027 created "2016-06-24" @default.
• W2309351027 creator A5006250732 @default.
• W2309351027 creator A5011600927 @default.
• W2309351027 creator A5032792357 @default.
• W2309351027 creator A5034470134 @default.
• W2309351027 creator A5036609300 @default.
• W2309351027 creator A5075180888 @default.
• W2309351027 creator A5077086042 @default.
• W2309351027 date "2016-02-01" @default.
• W2309351027 modified "2023-10-05" @default.
• W2309351027 title "Inhibition of Spinal Microglia and Astrocytes Contributes to the Anti-Allodynic Effect of Electroacupuncture in Neuropathic Pain Induced by Spinal Nerve Ligation" @default.
• W2309351027 cites W1965866432 @default.
• W2309351027 cites W1970954587 @default.
• W2309351027 cites W1974032221 @default.
• W2309351027 cites W1977736253 @default.
• W2309351027 cites W1980308568 @default.
• W2309351027 cites W1982534244 @default.
• W2309351027 cites W1990445317 @default.
• W2309351027 cites W2001805740 @default.
• W2309351027 cites W2009761130 @default.
• W2309351027 cites W2015676327 @default.
• W2309351027 cites W2016448869 @default.
• W2309351027 cites W2020244297 @default.
• W2309351027 cites W2030008286 @default.
• W2309351027 cites W2049140862 @default.
• W2309351027 cites W2063335342 @default.
• W2309351027 cites W2072449546 @default.
• W2309351027 cites W2073649371 @default.
• W2309351027 cites W2085384344 @default.
• W2309351027 cites W2112771663 @default.
• W2309351027 cites W2125480077 @default.
• W2309351027 cites W2126575561 @default.
• W2309351027 cites W2140441724 @default.
• W2309351027 cites W2162730620 @default.
• W2309351027 cites W2171396145 @default.
• W2309351027 cites W4233822115 @default.
• W2309351027 doi "https://doi.org/10.1136/acupmed-2015-010773" @default.
• W2309351027 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26177687" @default.
• W2309351027 hasPublicationYear "2016" @default.
• W2309351027 type Work @default.
• W2309351027 sameAs 2309351027 @default.
• W2309351027 citedByCount "43" @default.
• W2309351027 countsByYear W23093510272015 @default.
• W2309351027 countsByYear W23093510272016 @default.
• W2309351027 countsByYear W23093510272017 @default.
• W2309351027 countsByYear W23093510272018 @default.
• W2309351027 countsByYear W23093510272019 @default.
• W2309351027 countsByYear W23093510272020 @default.
• W2309351027 countsByYear W23093510272021 @default.
• W2309351027 countsByYear W23093510272022 @default.
• W2309351027 crossrefType "journal-article" @default.
• W2309351027 hasAuthorship W2309351027A5006250732 @default.
• W2309351027 hasAuthorship W2309351027A5011600927 @default.
• W2309351027 hasAuthorship W2309351027A5032792357 @default.
• W2309351027 hasAuthorship W2309351027A5034470134 @default.
• W2309351027 hasAuthorship W2309351027A5036609300 @default.
• W2309351027 hasAuthorship W2309351027A5075180888 @default.
• W2309351027 hasAuthorship W2309351027A5077086042 @default.
• W2309351027 hasConcept C118552586 @default.
• W2309351027 hasConcept C126322002 @default.
• W2309351027 hasConcept C134018914 @default.
• W2309351027 hasConcept C142724271 @default.
• W2309351027 hasConcept C179437574 @default.
• W2309351027 hasConcept C204232928 @default.
• W2309351027 hasConcept C204787440 @default.
• W2309351027 hasConcept C2776202274 @default.
• W2309351027 hasConcept C2776914184 @default.
• W2309351027 hasConcept C2777107010 @default.
• W2309351027 hasConcept C2777542381 @default.
• W2309351027 hasConcept C2779830541 @default.
• W2309351027 hasConcept C2780495277 @default.
• W2309351027 hasConcept C2780775167 @default.
• W2309351027 hasConcept C42219234 @default.
• W2309351027 hasConcept C529278444 @default.
• W2309351027 hasConcept C56837625 @default.
• W2309351027 hasConcept C71924100 @default.
• W2309351027 hasConceptScore W2309351027C118552586 @default.
• W2309351027 hasConceptScore W2309351027C126322002 @default.
• W2309351027 hasConceptScore W2309351027C134018914 @default.
• W2309351027 hasConceptScore W2309351027C142724271 @default.
• W2309351027 hasConceptScore W2309351027C179437574 @default.
• W2309351027 hasConceptScore W2309351027C204232928 @default.
• W2309351027 hasConceptScore W2309351027C204787440 @default.
• W2309351027 hasConceptScore W2309351027C2776202274 @default.
• W2309351027 hasConceptScore W2309351027C2776914184 @default.
• W2309351027 hasConceptScore W2309351027C2777107010 @default.
• W2309351027 hasConceptScore W2309351027C2777542381 @default.
• W2309351027 hasConceptScore W2309351027C2779830541 @default.
• W2309351027 hasConceptScore W2309351027C2780495277 @default.
• W2309351027 hasConceptScore W2309351027C2780775167 @default.
• W2309351027 hasConceptScore W2309351027C42219234 @default.
• W2309351027 hasConceptScore W2309351027C529278444 @default.
• W2309351027 hasConceptScore W2309351027C56837625 @default.
• W2309351027 hasConceptScore W2309351027C71924100 @default.
• W2309351027 hasIssue "1" @default.
• W2309351027 hasLocation W23093510271 @default.
• W2309351027 hasLocation W23093510272 @default.

• next