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• W2309374135 abstract "The mechanisms underlying nuclear body (NB) formation and their contribution to genome function are unknown. Here we examined the non-random positioning of Cajal bodies (CBs), major NBs involved in spliceosomal snRNP assembly and their role in genome organization. CBs are predominantly located at the periphery of chromosome territories at a multi-chromosome interface. Genome-wide chromosome conformation capture analysis (4C-seq) using CB-interacting loci revealed that CB-associated regions are enriched with highly expressed histone genes and U small nuclear or nucleolar RNA (sn/snoRNA) loci that form intra- and inter-chromosomal clusters. In particular, we observed a number of CB-dependent gene-positioning events on chromosome 1. RNAi-mediated disassembly of CBs disrupts the CB-targeting gene clusters and suppresses the expression of U sn/snoRNA and histone genes. This loss of spliceosomal snRNP production results in increased splicing noise, even in CB-distal regions. Therefore, we conclude that CBs contribute to genome organization with global effects on gene expression and RNA splicing fidelity." @default.
• W2309374135 created "2016-06-24" @default.
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• W2309374135 date "2016-03-21" @default.
• W2309374135 modified "2023-10-18" @default.
• W2309374135 title "Cajal bodies are linked to genome conformation" @default.
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• W2309374135 doi "https://doi.org/10.1038/ncomms10966" @default.
• W2309374135 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4802181" @default.
• W2309374135 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26997247" @default.
• W2309374135 hasPublicationYear "2016" @default.
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