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• W2309462153 endingPage "205" @default.
• W2309462153 startingPage "195" @default.
• W2309462153 abstract "ABSTRACT This paper examines the role of the extracellular matrix (ECM) in the development of the cornea. After a brief summary of the corneal structure and ECM, we describe evidence suggesting that the differen-tiation of neural crest (NC) cells into endothelium and fibroblasts is under the control of ocular ECM. We then examine the role of collagen I in stromal morpho-genesis by comparing normal corneas with those of homozygous Movl3 mice which do not make collagen We report that, in spite of this absence, the cellular morphology of the Movl3 eye is indistinguishable from that of the wild type. In the 16-day mutant stroma, however, the remaining collagens form small amounts of disorganized, thin fibrils rather than orthogonally organized 20 nm-diameter fibrils; a re-sult implying that collagen I plays only a structural role and that its absence is not compensated for. It also suggests that, because these remaining collagens will not form the normal fibrils that they will in vitro, fibrillogenesis in the corneal stroma differs from that elsewhere. The latter part of the paper describes our current work on chick stromal deposition using corneal epi-thelia isolated with an intact basal lamina that lay down in vitro ∼3 /im-thick stromas of organized fibrils similar to that seen in vivo. This experimental system has yielded two unexpected results. First, the amount of collagen and proteoglycans produced by such epi-thelia is not dependent on whether its substratum is collagenous and we therefore conclude that stromal production by the intact epithelium is more auton-omous than hitherto thought. Second, chondroitin sulphate (CS), the predominant proteoglycan, appears to play no role in stromal morphogenesis: epithelia cultured in testicular hyaluronidase, which degrades CS, lay down stromas whose organization and fibril-diameter distribution are indistinguishable from con-trols. One possible role for CS, however, is as a lubricant which facilitates corneal growth: it could allow fibrils to move over one another without deform-ing their orthogonal organization. Finally, we have examined the processes of fibrillogenesis in the corneal stroma and conclude that they are different from those elsewhere in the embryo and in vitro, perhaps because there is in the primary stroma an unidentified, highly hydrated ECM macromolecule that embeds the fibrils and that may mediate their morphogenesis." @default.
• W2309462153 created "2016-06-24" @default.
• W2309462153 creator A5024112044 @default.
• W2309462153 creator A5041987387 @default.
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• W2309462153 date "1988-09-01" @default.
• W2309462153 modified "2023-10-02" @default.
• W2309462153 title "The extracellular matrix of the developing cornea: diversity, deposition and function*" @default.
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• W2309462153 doi "https://doi.org/10.1242/dev.103.supplement.195" @default.
• W2309462153 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3250851" @default.
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