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• W2309474928 endingPage "90" @default.
• W2309474928 startingPage "78" @default.
• W2309474928 abstract "Due to their widespread use, organophosphate flame retardants (OPFRs) are commonly detected in various environmental matrices and have been identified as emerging contaminants. Considering the adverse effects of OPFRs, many researchers have paid their attention on the absorption, bioaccumulation, metabolism and internal exposure processes of OPFRs in animals and humans. In this article, we first review the diverse absorption routes of OPFRs by animals and humans (e.g., inhalation, ingestion, dermal absorption and gill absorption). Bioaccumulation and biomagnification potentials of OPFRs in different types of organisms and food webs are also summarized, based on quite limited available data and results. For metabolism, we review the Phase-I and Phase-II metabolic processes for each type of OPFRs (chlorinated OPFRs, alkyl-OPFRs and aryl-OPFRs) in the animals and humans, as well as toxicokinetic information and putative exposure biomarkers on OPFRs. Finally, we highlight gaps in our knowledge and critical directions for future internal exposure studies of OPFRs in animals and humans." @default.
• W2309474928 created "2016-06-24" @default.
• W2309474928 creator A5011647399 @default.
• W2309474928 creator A5033462059 @default.
• W2309474928 creator A5041950576 @default.
• W2309474928 date "2016-06-01" @default.
• W2309474928 modified "2023-10-17" @default.
• W2309474928 title "Review of OPFRs in animals and humans: Absorption, bioaccumulation, metabolism, and internal exposure research" @default.
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• W2309474928 doi "https://doi.org/10.1016/j.chemosphere.2016.03.003" @default.
• W2309474928 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27010170" @default.

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