FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2309498685> ?p ?o ?g. }

• W2309498685 abstract "The differences between males and females are a socially delicate topic that is biologically fascinating. It turns out that sex differences exist in embryos even before implantation into the uterus, and one important embryonic difference between males and females is response to maternal inflammation. Knowing that inflammation can be detrimental to successful implantation, a clinical trial (called EAGeR, Effects of Aspirin in Gestation and Reproduction) was conducted to study whether preconception low-dose aspirin (LDA, 81 mg daily) could improve pregnancy and live birth rates in women who previously had one or two miscarriages. Schisterman and his team reported in the Lancet last year that LDA did not improve these outcomes. Interestingly however, the same team now asked: Are male embryos more sensitive and vulnerable to the detrimental effects of maternal inflammation, and if yes, can this risk to male survival be ameliorated with low-dose aspirin?Radin et al . analyzed the data from the 1086 EAGeR trial participants and found that women receiving LDA were more likely to become pregnant with, and give birth to, a male. To put some numbers on this, 31% of the women on LDA versus 23% on placebo gave birth to a male offspring, which computes to a risk ratio of 1.31 and a risk difference of 7.18 per 100 women. The probability of having a female infant was unaltered, highlighting that this response is sex-specific. Further stratification of the patients based on their high-sensitivity C-reactive protein (hsCRP, indicative of inflammation) confirmed the heightened vulnerability of male embryos to maternal inflammation with a striking association between hsCRP concentration and reduced sex ratio (fewer males) in the placebo group. The analysis also revealed that the patients with the highest hsCRP (range ~2-62 mg/L) had the strongest response to LDA in terms of male pregnancy incidence. This study is the first to show in humans that response to maternal inflammation is sexually dimorphic. An understanding of the specific features of inflammation that are hazardous to male embryos, the mechanisms underlying the biological fragility of male embryos and/or the resistance of females to the same stressors, and whether the divergent response to stressors persists through life thus contributing to the differential risk of inflammation-associated diseases is anticipated to be of wide clinical importance.R. G. Radin et al ., Sex ratio following preconception low-dose aspirin in women with prior pregnancy loss. J. Clin. Invest . 10.1172/JCI82357 (2015). [[Full Text]][1] [1]: http://www.jci.org/articles/view/82357" @default.
• W2309498685 created "2016-06-24" @default.
• W2309498685 creator A5066408267 @default.
• W2309498685 date "2015-09-02" @default.
• W2309498685 modified "2023-09-23" @default.
• W2309498685 title "Early evidence of male sensitivity" @default.
• W2309498685 doi "https://doi.org/10.1126/scitranslmed.aad1830" @default.
• W2309498685 hasPublicationYear "2015" @default.
• W2309498685 type Work @default.
• W2309498685 sameAs 2309498685 @default.
• W2309498685 citedByCount "0" @default.
• W2309498685 crossrefType "journal-article" @default.
• W2309498685 hasAuthorship W2309498685A5066408267 @default.
• W2309498685 hasConcept C112672928 @default.
• W2309498685 hasConcept C126322002 @default.
• W2309498685 hasConcept C131872663 @default.
• W2309498685 hasConcept C142724271 @default.
• W2309498685 hasConcept C204787440 @default.
• W2309498685 hasConcept C27081682 @default.
• W2309498685 hasConcept C2776914184 @default.
• W2309498685 hasConcept C2777628954 @default.
• W2309498685 hasConcept C2779234561 @default.
• W2309498685 hasConcept C42407357 @default.
• W2309498685 hasConcept C46973012 @default.
• W2309498685 hasConcept C54355233 @default.
• W2309498685 hasConcept C71924100 @default.
• W2309498685 hasConcept C86803240 @default.
• W2309498685 hasConceptScore W2309498685C112672928 @default.
• W2309498685 hasConceptScore W2309498685C126322002 @default.
• W2309498685 hasConceptScore W2309498685C131872663 @default.
• W2309498685 hasConceptScore W2309498685C142724271 @default.
• W2309498685 hasConceptScore W2309498685C204787440 @default.
• W2309498685 hasConceptScore W2309498685C27081682 @default.
• W2309498685 hasConceptScore W2309498685C2776914184 @default.
• W2309498685 hasConceptScore W2309498685C2777628954 @default.
• W2309498685 hasConceptScore W2309498685C2779234561 @default.
• W2309498685 hasConceptScore W2309498685C42407357 @default.
• W2309498685 hasConceptScore W2309498685C46973012 @default.
• W2309498685 hasConceptScore W2309498685C54355233 @default.
• W2309498685 hasConceptScore W2309498685C71924100 @default.
• W2309498685 hasConceptScore W2309498685C86803240 @default.
• W2309498685 hasLocation W23094986851 @default.
• W2309498685 hasOpenAccess W2309498685 @default.
• W2309498685 hasPrimaryLocation W23094986851 @default.
• W2309498685 hasRelatedWork W154456846 @default.
• W2309498685 hasRelatedWork W1994608797 @default.
• W2309498685 hasRelatedWork W1996191814 @default.
• W2309498685 hasRelatedWork W1997339370 @default.
• W2309498685 hasRelatedWork W2008035850 @default.
• W2309498685 hasRelatedWork W2075971172 @default.
• W2309498685 hasRelatedWork W2116608844 @default.
• W2309498685 hasRelatedWork W2177363559 @default.
• W2309498685 hasRelatedWork W2226113296 @default.
• W2309498685 hasRelatedWork W2333603713 @default.
• W2309498685 hasRelatedWork W2405488232 @default.
• W2309498685 hasRelatedWork W2409190472 @default.
• W2309498685 hasRelatedWork W2759186534 @default.
• W2309498685 hasRelatedWork W2806942227 @default.
• W2309498685 hasRelatedWork W2922591672 @default.
• W2309498685 hasRelatedWork W2977671273 @default.
• W2309498685 hasRelatedWork W3087654809 @default.
• W2309498685 hasRelatedWork W3184478567 @default.
• W2309498685 hasRelatedWork W8270881 @default.
• W2309498685 hasRelatedWork W2176233945 @default.
• W2309498685 isParatext "false" @default.
• W2309498685 isRetracted "false" @default.
• W2309498685 magId "2309498685" @default.
• W2309498685 workType "article" @default.