FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2309551856> ?p ?o ?g. }

• W2309551856 endingPage "425" @default.
• W2309551856 startingPage "419" @default.
• W2309551856 abstract "The dynamic motions of protein structural elements, particularly flexible loops, are intimately linked with diverse aspects of enzyme catalysis. Engineering of these loop regions can alter protein stability, substrate binding and even dramatically impact enzyme function. When these flexible regions are unresolvable structurally, computational reconstruction in combination with large-scale molecular dynamics simulations can be used to guide the engineering strategy. Here we present a collaborative approach that consists of both experiment and computation and led to the discovery of a single mutation in the F/G loop of the nitrating cytochrome P450 TxtE that simultaneously controls loop dynamics and completely shifts the enzyme's regioselectivity from the C4 to the C5 position of L-tryptophan. Furthermore, we find that this loop mutation is naturally present in a subset of homologous nitrating P450s and confirm that these uncharacterized enzymes exclusively produce 5-nitro-L-tryptophan, a previously unknown biosynthetic intermediate." @default.
• W2309551856 created "2016-06-24" @default.
• W2309551856 creator A5012048639 @default.
• W2309551856 creator A5019581942 @default.
• W2309551856 creator A5020281785 @default.
• W2309551856 creator A5032418986 @default.
• W2309551856 creator A5053353039 @default.
• W2309551856 creator A5081226757 @default.
• W2309551856 date "2016-03-21" @default.
• W2309551856 modified "2023-10-06" @default.
• W2309551856 title "Discovery of a regioselectivity switch in nitrating P450s guided by molecular dynamics simulations and Markov models" @default.
• W2309551856 cites W1557220951 @default.
• W2309551856 cites W1614630012 @default.
• W2309551856 cites W1824276531 @default.
• W2309551856 cites W1825535009 @default.
• W2309551856 cites W1973029987 @default.
• W2309551856 cites W1981407107 @default.
• W2309551856 cites W1986655133 @default.
• W2309551856 cites W1991129365 @default.
• W2309551856 cites W1996903743 @default.
• W2309551856 cites W2002678890 @default.
• W2309551856 cites W2009290044 @default.
• W2309551856 cites W2016336300 @default.
• W2309551856 cites W2025753091 @default.
• W2309551856 cites W2034158879 @default.
• W2309551856 cites W2035532840 @default.
• W2309551856 cites W2035819928 @default.
• W2309551856 cites W2035964297 @default.
• W2309551856 cites W2036437452 @default.
• W2309551856 cites W2037805556 @default.
• W2309551856 cites W2049888624 @default.
• W2309551856 cites W2050329397 @default.
• W2309551856 cites W2050679888 @default.
• W2309551856 cites W2053448443 @default.
• W2309551856 cites W2060686710 @default.
• W2309551856 cites W2062683863 @default.
• W2309551856 cites W2063404521 @default.
• W2309551856 cites W2080580475 @default.
• W2309551856 cites W2097159156 @default.
• W2309551856 cites W2108738397 @default.
• W2309551856 cites W2111334080 @default.
• W2309551856 cites W2112271922 @default.
• W2309551856 cites W2129981743 @default.
• W2309551856 cites W2131017257 @default.
• W2309551856 cites W2135789833 @default.
• W2309551856 cites W2140158011 @default.
• W2309551856 cites W2140889813 @default.
• W2309551856 cites W2162328331 @default.
• W2309551856 cites W2167737794 @default.
• W2309551856 cites W2178929802 @default.
• W2309551856 cites W2215677265 @default.
• W2309551856 cites W2328443973 @default.
• W2309551856 cites W2465454845 @default.
• W2309551856 cites W3213568968 @default.
• W2309551856 cites W423419411 @default.
• W2309551856 doi "https://doi.org/10.1038/nchem.2474" @default.
• W2309551856 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4843824" @default.
• W2309551856 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27102675" @default.
• W2309551856 hasPublicationYear "2016" @default.
• W2309551856 type Work @default.
• W2309551856 sameAs 2309551856 @default.
• W2309551856 citedByCount "103" @default.
• W2309551856 countsByYear W23095518562016 @default.
• W2309551856 countsByYear W23095518562017 @default.
• W2309551856 countsByYear W23095518562018 @default.
• W2309551856 countsByYear W23095518562019 @default.
• W2309551856 countsByYear W23095518562020 @default.
• W2309551856 countsByYear W23095518562021 @default.
• W2309551856 countsByYear W23095518562022 @default.
• W2309551856 countsByYear W23095518562023 @default.
• W2309551856 crossrefType "journal-article" @default.
• W2309551856 hasAuthorship W2309551856A5012048639 @default.
• W2309551856 hasAuthorship W2309551856A5019581942 @default.
• W2309551856 hasAuthorship W2309551856A5020281785 @default.
• W2309551856 hasAuthorship W2309551856A5032418986 @default.
• W2309551856 hasAuthorship W2309551856A5053353039 @default.
• W2309551856 hasAuthorship W2309551856A5081226757 @default.
• W2309551856 hasBestOaLocation W23095518562 @default.
• W2309551856 hasConcept C104317684 @default.
• W2309551856 hasConcept C143065580 @default.
• W2309551856 hasConcept C147597530 @default.
• W2309551856 hasConcept C147816474 @default.
• W2309551856 hasConcept C161790260 @default.
• W2309551856 hasConcept C181199279 @default.
• W2309551856 hasConcept C185592680 @default.
• W2309551856 hasConcept C186060115 @default.
• W2309551856 hasConcept C2775981520 @default.
• W2309551856 hasConcept C55493867 @default.
• W2309551856 hasConcept C59593255 @default.
• W2309551856 hasConcept C59759590 @default.
• W2309551856 hasConcept C70721500 @default.
• W2309551856 hasConcept C71240020 @default.
• W2309551856 hasConcept C86803240 @default.
• W2309551856 hasConcept C9418097 @default.
• W2309551856 hasConceptScore W2309551856C104317684 @default.
• W2309551856 hasConceptScore W2309551856C143065580 @default.
• W2309551856 hasConceptScore W2309551856C147597530 @default.
• W2309551856 hasConceptScore W2309551856C147816474 @default.

• next