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- W2309554392 abstract "The present study is aimed at understanding the underlying mechanisms of the neuronal adaptation in the brain. An integrated model of signaling dynamics elicited by neuropeptide receptors and the electrophysiology was developed and the interactions were analyzed. The biological system considered is that of brainstem neurons in which the dynamic changes in the neuronal excitability are elicited by Angiotensin II. The model is based on the available kinetics of Gq-protein coupled receptor signaling, known ion channel components and the corresponding models based on Hodgkin-Huxley framework, and relies on experimentally motivated assumptions on the phosphorylation kinetics of ion channels to couple the two domains. This model is in concordance with the experimental data and exhibits an AngIIelicited increase in neuronal excitability. One of the key hypotheses of the integrated model is the compartmentalization of the calcium levels between the membrane ion channels and cytosol. Analysis of the model for different cases of interactions revealed the individual contribution of the key signaling kinases to the overall adaptation dynamics. These experimentally verifiable hypotheses provide insights into the dynamics of interactions between signaling and electrophysiology that underlie neuronal adaptation in the brain." @default.
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- W2309554392 date "2007-01-01" @default.
- W2309554392 modified "2023-09-27" @default.
- W2309554392 title "Modeling Neuronal Adaptation in the Brain: Integrating Receptor Signaling and Electrophysiology" @default.
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