Matches in SemOpenAlex for { <https://semopenalex.org/work/W2309559670> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2309559670 endingPage "1437" @default.
- W2309559670 startingPage "1431" @default.
- W2309559670 abstract "Infants with respiratory failure are frequently mechanically ventilated at rates exceeding 60 breaths/min. We analyzed the effect of ventilatory rates of 30, 60, and 90 breaths/min (inspiratory times of 0.6, 0.3, and 0.2 s, respectively) on the pressure-flow relationships of the lungs of anesthetized paralyzed rabbits after saline lavage. Tidal volume and functional residual capacity were maintained constant. We computed effective inspiratory and expiratory resistance and compliance of the lungs by dividing changes in transpulmonary pressure into resistive and elastic components with a multiple linear regression. We found that mean pulmonary resistance was lower at higher ventilatory rates, while pulmonary compliance was independent of ventilatory rate. The transpulmonary pressure developed by the ventilator during inspiration approximated a linear ramp. Gas flow became constant and the pressure-volume relationship linear during the last portion of inspiration. Even at a ventilatory rate of 90 breaths/min, 28–56% of the tidal volume was delivered with a constant inspiratory flow. Our findings are consistent with the model of Bates et al. (J. Appl. Physiol. 58: 1840–1848, 1985), wherein the distribution of gas flow within the lungs depends predominantly on resistive factors while inspiratory flow is increasing, and on elastic factors while inspiratory flow is constant. This dynamic behavior of the surfactant-depleted lungs suggests that, even with very short inspiratory times, distribution of gas flow within the lungs is in large part determined by elastic factors. Unless the inspiratory time is further shortened, gas flow may be directed to areas of increased resistance, resulting in hyperinflation and barotrauma." @default.
- W2309559670 created "2016-06-24" @default.
- W2309559670 creator A5007329649 @default.
- W2309559670 creator A5030355928 @default.
- W2309559670 creator A5045953332 @default.
- W2309559670 creator A5084687045 @default.
- W2309559670 date "1986-10-01" @default.
- W2309559670 modified "2023-09-27" @default.
- W2309559670 title "Pulmonary mechanics during rapid mechanical ventilation in rabbits with saline-lavaged lungs" @default.
- W2309559670 doi "https://doi.org/10.1152/jappl.1986.61.4.1431" @default.
- W2309559670 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3096938" @default.
- W2309559670 hasPublicationYear "1986" @default.
- W2309559670 type Work @default.
- W2309559670 sameAs 2309559670 @default.
- W2309559670 citedByCount "4" @default.
- W2309559670 crossrefType "journal-article" @default.
- W2309559670 hasAuthorship W2309559670A5007329649 @default.
- W2309559670 hasAuthorship W2309559670A5030355928 @default.
- W2309559670 hasAuthorship W2309559670A5045953332 @default.
- W2309559670 hasAuthorship W2309559670A5084687045 @default.
- W2309559670 hasConcept C121332964 @default.
- W2309559670 hasConcept C126322002 @default.
- W2309559670 hasConcept C136936797 @default.
- W2309559670 hasConcept C153899047 @default.
- W2309559670 hasConcept C15744967 @default.
- W2309559670 hasConcept C163498912 @default.
- W2309559670 hasConcept C164705383 @default.
- W2309559670 hasConcept C200457457 @default.
- W2309559670 hasConcept C27101514 @default.
- W2309559670 hasConcept C2777080012 @default.
- W2309559670 hasConcept C2777257755 @default.
- W2309559670 hasConcept C2777397205 @default.
- W2309559670 hasConcept C2777421782 @default.
- W2309559670 hasConcept C2777714996 @default.
- W2309559670 hasConcept C2777785262 @default.
- W2309559670 hasConcept C2781460075 @default.
- W2309559670 hasConcept C42219234 @default.
- W2309559670 hasConcept C534529494 @default.
- W2309559670 hasConcept C56283660 @default.
- W2309559670 hasConcept C71924100 @default.
- W2309559670 hasConcept C77805123 @default.
- W2309559670 hasConcept C97355855 @default.
- W2309559670 hasConceptScore W2309559670C121332964 @default.
- W2309559670 hasConceptScore W2309559670C126322002 @default.
- W2309559670 hasConceptScore W2309559670C136936797 @default.
- W2309559670 hasConceptScore W2309559670C153899047 @default.
- W2309559670 hasConceptScore W2309559670C15744967 @default.
- W2309559670 hasConceptScore W2309559670C163498912 @default.
- W2309559670 hasConceptScore W2309559670C164705383 @default.
- W2309559670 hasConceptScore W2309559670C200457457 @default.
- W2309559670 hasConceptScore W2309559670C27101514 @default.
- W2309559670 hasConceptScore W2309559670C2777080012 @default.
- W2309559670 hasConceptScore W2309559670C2777257755 @default.
- W2309559670 hasConceptScore W2309559670C2777397205 @default.
- W2309559670 hasConceptScore W2309559670C2777421782 @default.
- W2309559670 hasConceptScore W2309559670C2777714996 @default.
- W2309559670 hasConceptScore W2309559670C2777785262 @default.
- W2309559670 hasConceptScore W2309559670C2781460075 @default.
- W2309559670 hasConceptScore W2309559670C42219234 @default.
- W2309559670 hasConceptScore W2309559670C534529494 @default.
- W2309559670 hasConceptScore W2309559670C56283660 @default.
- W2309559670 hasConceptScore W2309559670C71924100 @default.
- W2309559670 hasConceptScore W2309559670C77805123 @default.
- W2309559670 hasConceptScore W2309559670C97355855 @default.
- W2309559670 hasIssue "4" @default.
- W2309559670 hasLocation W23095596701 @default.
- W2309559670 hasLocation W23095596702 @default.
- W2309559670 hasOpenAccess W2309559670 @default.
- W2309559670 hasPrimaryLocation W23095596701 @default.
- W2309559670 hasRelatedWork W1904658675 @default.
- W2309559670 hasRelatedWork W2103668181 @default.
- W2309559670 hasRelatedWork W2108934505 @default.
- W2309559670 hasRelatedWork W2122768693 @default.
- W2309559670 hasRelatedWork W2167718580 @default.
- W2309559670 hasRelatedWork W2180509816 @default.
- W2309559670 hasRelatedWork W2279306282 @default.
- W2309559670 hasRelatedWork W2309559670 @default.
- W2309559670 hasRelatedWork W2340550853 @default.
- W2309559670 hasRelatedWork W2418706457 @default.
- W2309559670 hasVolume "61" @default.
- W2309559670 isParatext "false" @default.
- W2309559670 isRetracted "false" @default.
- W2309559670 magId "2309559670" @default.
- W2309559670 workType "article" @default.