Matches in SemOpenAlex for { <https://semopenalex.org/work/W2309778922> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2309778922 endingPage "141" @default.
- W2309778922 startingPage "130" @default.
- W2309778922 abstract "There is strong evidence that hormonally active agents (HAAs) such as Atrazine (ATZ), Cadmium (Cd), Arsenic (As) and Nitrate (NO 3 ) have both estrogenic activity and carcinogenic potential. Atrazine has clastogenic effects and may also act as tumor promoter as it induces the aromatase enzyme. Arsenic and Cadmium have been implicated in the etiology of skin, lung, prostate and liver cancers. Nitrate in drinking water has been found to increase the risk of bladder cancer. This study examined the genotoxicity of the aforementioned HAAs alone and in mixtures using mammalian breast cell lines, MCF-7 and MCF-10A, which are estrogen receptorpositive (ER+) and estrogen receptor-negative (ER-), respectively. To study the clastogenic potential by whole cell and flow karyotype damage, cells were exposed to environmentally relevant concentrations of ATZ, Cd, As and NO 3 for 4 and 7 days. Results indicated that all treatments induced whole cell clastogenicity in MCF-7 cells; except Cd and NO3 after 4 and 7 days as well as the 10% quaternary As mixture after 1 week. In MCF-10A cells, all treatments except the 10% mixture induced whole cell clastogenicity after 4 days, where flow karyotype damage was detected in all treatments except for the 10% mixture after 1 week. Estrogen caused whole cell damage but not flow karyotype damage in MCF-7. On the other hand, estrogen caused flow karyotype damage and not whole cell damage in MCF-10A cells, suggesting that estrogen receptor modulated the genotoxicity of estrogen. Cd caused flow karyotype damage but not whole cell damage in MCF-7 indicating that Cd’s gentoxicity is not related to its estrogenic activity. Keywords: HAAs, clastogenicity, flow-karyotype, genotoxicity, MCF-7, MCF-10A" @default.
- W2309778922 created "2016-06-24" @default.
- W2309778922 creator A5028674241 @default.
- W2309778922 creator A5054113352 @default.
- W2309778922 creator A5069029009 @default.
- W2309778922 creator A5074928426 @default.
- W2309778922 creator A5086617934 @default.
- W2309778922 creator A5087892403 @default.
- W2309778922 date "2014-01-01" @default.
- W2309778922 modified "2023-09-28" @default.
- W2309778922 title "Genotoxic Effect of Atrazine, Arsenic, Cadmium and Nitrate, Individually and in Mixtures at Maximum Contaminant Levels on mammalian Breast Cell Lines" @default.
- W2309778922 hasPublicationYear "2014" @default.
- W2309778922 type Work @default.
- W2309778922 sameAs 2309778922 @default.
- W2309778922 citedByCount "0" @default.
- W2309778922 crossrefType "journal-article" @default.
- W2309778922 hasAuthorship W2309778922A5028674241 @default.
- W2309778922 hasAuthorship W2309778922A5054113352 @default.
- W2309778922 hasAuthorship W2309778922A5069029009 @default.
- W2309778922 hasAuthorship W2309778922A5074928426 @default.
- W2309778922 hasAuthorship W2309778922A5086617934 @default.
- W2309778922 hasAuthorship W2309778922A5087892403 @default.
- W2309778922 hasConcept C121608353 @default.
- W2309778922 hasConcept C126322002 @default.
- W2309778922 hasConcept C134018914 @default.
- W2309778922 hasConcept C141710004 @default.
- W2309778922 hasConcept C143425029 @default.
- W2309778922 hasConcept C185592680 @default.
- W2309778922 hasConcept C2777164284 @default.
- W2309778922 hasConcept C2778959862 @default.
- W2309778922 hasConcept C2780358455 @default.
- W2309778922 hasConcept C29730261 @default.
- W2309778922 hasConcept C530470458 @default.
- W2309778922 hasConcept C552990157 @default.
- W2309778922 hasConcept C55493867 @default.
- W2309778922 hasConcept C71924100 @default.
- W2309778922 hasConcept C84606932 @default.
- W2309778922 hasConcept C86803240 @default.
- W2309778922 hasConceptScore W2309778922C121608353 @default.
- W2309778922 hasConceptScore W2309778922C126322002 @default.
- W2309778922 hasConceptScore W2309778922C134018914 @default.
- W2309778922 hasConceptScore W2309778922C141710004 @default.
- W2309778922 hasConceptScore W2309778922C143425029 @default.
- W2309778922 hasConceptScore W2309778922C185592680 @default.
- W2309778922 hasConceptScore W2309778922C2777164284 @default.
- W2309778922 hasConceptScore W2309778922C2778959862 @default.
- W2309778922 hasConceptScore W2309778922C2780358455 @default.
- W2309778922 hasConceptScore W2309778922C29730261 @default.
- W2309778922 hasConceptScore W2309778922C530470458 @default.
- W2309778922 hasConceptScore W2309778922C552990157 @default.
- W2309778922 hasConceptScore W2309778922C55493867 @default.
- W2309778922 hasConceptScore W2309778922C71924100 @default.
- W2309778922 hasConceptScore W2309778922C84606932 @default.
- W2309778922 hasConceptScore W2309778922C86803240 @default.
- W2309778922 hasIssue "2" @default.
- W2309778922 hasLocation W23097789221 @default.
- W2309778922 hasOpenAccess W2309778922 @default.
- W2309778922 hasPrimaryLocation W23097789221 @default.
- W2309778922 hasRelatedWork W1964993473 @default.
- W2309778922 hasRelatedWork W1990385537 @default.
- W2309778922 hasRelatedWork W2018659656 @default.
- W2309778922 hasRelatedWork W2025015647 @default.
- W2309778922 hasRelatedWork W2026474885 @default.
- W2309778922 hasRelatedWork W2049128182 @default.
- W2309778922 hasRelatedWork W2063231187 @default.
- W2309778922 hasRelatedWork W2086757547 @default.
- W2309778922 hasRelatedWork W2093663127 @default.
- W2309778922 hasRelatedWork W2119794661 @default.
- W2309778922 hasRelatedWork W2156274141 @default.
- W2309778922 hasRelatedWork W2182344361 @default.
- W2309778922 hasRelatedWork W2184441088 @default.
- W2309778922 hasRelatedWork W2418704502 @default.
- W2309778922 hasRelatedWork W2464223615 @default.
- W2309778922 hasRelatedWork W2888938751 @default.
- W2309778922 hasRelatedWork W2916282871 @default.
- W2309778922 hasRelatedWork W3004215680 @default.
- W2309778922 hasRelatedWork W3140353348 @default.
- W2309778922 hasRelatedWork W2184267998 @default.
- W2309778922 hasVolume "2" @default.
- W2309778922 isParatext "false" @default.
- W2309778922 isRetracted "false" @default.
- W2309778922 magId "2309778922" @default.
- W2309778922 workType "article" @default.