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- W2309807471 abstract "ABSTRACT Aim: Background: Treatment of borderline ovarian tumors (BOT) remains contentious. Regarding invasive implants, there is no consensus regarding therapy. This article evaluates the benefits of platinum-based adjuvant treatment in patients with BOT. Methods: Methods: The PubMed and Cochrane Library databases were systematically searched for articles using the terms ((Borderline) OR (low malignant potential) AND (ovarian)) AND ((tumor) OR (cancer)) AND ((follow-up) OR (survival) OR (treatment) OR (chemotherapy) OR (adjuvant treatment)). Results: Results: We identified 31 articles including 4982 patients. Together 623 patients presented non-invasive-, 184 invasive- and 91 unspecified implants. Central pathological examination was performed in 23 studies. Nine studies included more than 90% stage I patients, while 10 included only advanced stage patients. Nineteen studies reported patients undergoing complete cytoreduction, 10 reported response rates and 9 compared survival outcomes. All studies provided information regarding either mortality or recurrence rates. A meta-analysis of the 13 studies providing separate mortality data for both treatment groups, including 2206 women, favored surgical treatment only (OR = 7,44 95%CI = 3,39-16,32; p Conclusions: Conclusions: We do not find evidence supporting platinum-based adjuvant therapy for BOT, including in patients with invasive implants. Nonetheless, it's likely that the small sub-group of patients relapsing as high-grade ovarian carcinoma will profit from adjuvant treatment. Disclosure: All authors have declared no conflicts of interest." @default.
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- W2309807471 date "2014-09-01" @default.
- W2309807471 modified "2023-09-29" @default.
- W2309807471 title "The Impact of Platinum-Based Adjuvant Treatment on the Outcome of Borderline Ovarian Tumors: a Meta-Analysis" @default.
- W2309807471 doi "https://doi.org/10.1093/annonc/mdu338.26" @default.
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