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- W230988150 abstract "While remarkable progress has been made in strategies for cancer treatment, strategies for cancer pain management are still in their infancy with respect to translating results from animal models to the clinical setting, due to the complex biopsychosocial nature of cancer pain. Although conventional cancer pain management based on the World Health Organization three-step ladder may serve well for the majority of patients, up to 30% of patients with cancer pain may not benefit from the standard approach. The strategy of switching from one opioid analgesic to another, in order to overcome worsening side effects while attempting to improve analgesic efficacy, has been empirically accepted. This practice has been strongly based on the assumed equianalgesic dose ratio between opioids. However, the growing realization of opioid-induced hyperalgesia and the role of methadone in receptor recycling have provided new insights into the mechanism of cancer pain that does not respond to conventional opioid treatment. As cancer is no longer considered a terminal disease, concern has been raised about the side effects of long-term opioid therapy. Although methadone has been recognized as pharmacokinetically challenging to use, its unique pharmacodynamic properties may provide advantages over other opioid analgesics. Establishing phenotypes that respond to certain types of approach may help clinicians to stratify the approach further." @default.
- W230988150 created "2016-06-24" @default.
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- W230988150 date "2014-12-01" @default.
- W230988150 modified "2023-10-11" @default.
- W230988150 title "Potential Role and Challenges of Methadone in Cancer Pain Management" @default.
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