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• W2310009570 abstract "In the course of screening for apoptotic substances that induce apoptosis in human leukemia U937 cells, a fungal strain, F000487, which exhibits potent inducible activity, was selected. The active compound was purified from an ethyl acetate extract of the microorganism by Sep-pak C18 column chromatography and HPLC, and was identified as atromentin by spectroscopic methods. This compound induced caspase-3 processing in human leukemia U937 cells. The caspase-3 and poly (ADP-ribose) polymerase (PARP) were induced by atromentin in a dose-dependent manner. Furthermore, DNA fragmentation was also induced by this compound in a dose-dependent manner. These results show that atromentin potently induces apoptosis in U937 cells and that atromentin-induced apoptosis is related to the selective activation of caspases." @default.
• W2310009570 created "2016-06-24" @default.
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• W2310009570 date "2009-09-28" @default.
• W2310009570 modified "2023-09-29" @default.
• W2310009570 title "Atromentin-Induced Apoptosis in Human Leukemia U937 Cells" @default.
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• W2310009570 doi "https://doi.org/10.4014/jmb.0811.617" @default.
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