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• W2310052766 abstract "Activated AMPK protects the heart from cardiac ischemia-reperfusion (IR) injury and is associated with inhibition of mitochondrial permeability transition pore (PTP) opening. On the other hand, pharmacological inhibition of the PTP reduces infarct size and improves cardiac function. However, it is unclear whether beneficial effects of AMPK are mediated through the PTP and, if they are not, whether simultaneous activation of AMPK and inhibition of the PTP exert synergistic protective effects against cardiac IR injury. Here, we examined the effects of the AMPK activator, A-769662 in combination with the PTP inhibitor, sanglifehrin A (SfA) on in vivo cardiac IR. Cardiac dysfunction following IR injury was associated with decreased activity of the mitochondrial electron transport chain (ETC) and increased mitochondrial ROS and PTP opening. Administration of A-769662 or SfA individually upon reperfusion improved cardiac function, reduced infarction size, and inhibited ROS production and PTP opening. However, simultaneous administration of SfA and A-769662 did not provide synergistic improvement of postischemic recovery of cardiac and mitochondrial function, though both compounds disrupted IR-induced interaction between PPAR α and CyP-D. In conclusion, A-769662 or SfA prevents PPAR α interaction with CyP-D, improving cardiac outcomes and increasing mitochondrial function, and simultaneous administration of the drugs does not provide synergistic effects." @default.
• W2310052766 created "2016-06-24" @default.
• W2310052766 creator A5042828993 @default.
• W2310052766 creator A5080565124 @default.
• W2310052766 date "2016-01-01" @default.
• W2310052766 modified "2023-10-17" @default.
• W2310052766 title "Possible Role of Interaction between PPARαand Cyclophilin D in Cardioprotection of AMPK againstIn VivoIschemia-Reperfusion in Rats" @default.
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• W2310052766 doi "https://doi.org/10.1155/2016/9282087" @default.
• W2310052766 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4802016" @default.
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