FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2310073407> ?p ?o ?g. }

• W2310073407 endingPage "328" @default.
• W2310073407 startingPage "322" @default.
• W2310073407 abstract "Aims The aim of this study was to examine the expression of mismatch repair ( MMR ) proteins in Lynch syndrome ( LS )‐associated colorectal adenomas and to evaluate their relationship with clinicopathological variables and potential utility in LS screening. Methods and results We performed immunohistochemistry for MLH 1, PMS 2, MSH 2 and MSH 6 in 134 adenomas obtained from 26 genetically confirmed LS patients. MMR deficiency, as determined by loss of any MMR protein, was observed in 113 adenomas (84%). All the MMR ‐deficient adenomas exhibited homogeneous loss of MMR proteins, which reflected underlying germline mutations. MMR deficiency was more frequent in adenomas obtained from older patients (aged ≥60 years; 81 of 86, 94%), with larger tumour size (>5 mm; 71 of 73, 97%) and with high‐grade dysplasia (50 of 51, 98%). Multivariate analyses indicated that increased age and larger tumour size were associated independently with MMR deficiency. Conclusions This study shows that MMR deficiency is associated significantly with increased age, in addition to two previously reported factors–larger size and high‐grade dysplasia. When adenomas are analysed during LS screening, high sensitivity is expected if the adenomas are associated with any of these three factors." @default.
• W2310073407 created "2016-06-24" @default.
• W2310073407 creator A5001211200 @default.
• W2310073407 creator A5015262464 @default.
• W2310073407 creator A5023337772 @default.
• W2310073407 creator A5027931313 @default.
• W2310073407 creator A5046119070 @default.
• W2310073407 creator A5057200745 @default.
• W2310073407 creator A5059713499 @default.
• W2310073407 creator A5060602384 @default.
• W2310073407 date "2016-03-21" @default.
• W2310073407 modified "2023-10-04" @default.
• W2310073407 title "Mismatch repair deficiency in Lynch syndrome-associated colorectal adenomas is more prevalent in older patients" @default.
• W2310073407 cites W1533146179 @default.
• W2310073407 cites W1841354258 @default.
• W2310073407 cites W1893792948 @default.
• W2310073407 cites W1975305865 @default.
• W2310073407 cites W1993622089 @default.
• W2310073407 cites W2003056152 @default.
• W2310073407 cites W2026410750 @default.
• W2310073407 cites W2030080487 @default.
• W2310073407 cites W2036041958 @default.
• W2310073407 cites W2058438744 @default.
• W2310073407 cites W2062533273 @default.
• W2310073407 cites W2062716963 @default.
• W2310073407 cites W2068022193 @default.
• W2310073407 cites W2070123583 @default.
• W2310073407 cites W2072186927 @default.
• W2310073407 cites W2072879574 @default.
• W2310073407 cites W2095874417 @default.
• W2310073407 cites W2108496206 @default.
• W2310073407 cites W2109378245 @default.
• W2310073407 cites W2111067155 @default.
• W2310073407 cites W2112565258 @default.
• W2310073407 cites W2117221748 @default.
• W2310073407 cites W2117862895 @default.
• W2310073407 cites W2118826912 @default.
• W2310073407 cites W2126985514 @default.
• W2310073407 cites W2145297551 @default.
• W2310073407 cites W2147274538 @default.
• W2310073407 cites W2152162369 @default.
• W2310073407 cites W2158149329 @default.
• W2310073407 cites W2159899668 @default.
• W2310073407 cites W2163330492 @default.
• W2310073407 doi "https://doi.org/10.1111/his.12941" @default.
• W2310073407 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26826556" @default.
• W2310073407 hasPublicationYear "2016" @default.
• W2310073407 type Work @default.
• W2310073407 sameAs 2310073407 @default.
• W2310073407 citedByCount "13" @default.
• W2310073407 countsByYear W23100734072017 @default.
• W2310073407 countsByYear W23100734072018 @default.
• W2310073407 countsByYear W23100734072019 @default.
• W2310073407 countsByYear W23100734072020 @default.
• W2310073407 countsByYear W23100734072021 @default.
• W2310073407 crossrefType "journal-article" @default.
• W2310073407 hasAuthorship W2310073407A5001211200 @default.
• W2310073407 hasAuthorship W2310073407A5015262464 @default.
• W2310073407 hasAuthorship W2310073407A5023337772 @default.
• W2310073407 hasAuthorship W2310073407A5027931313 @default.
• W2310073407 hasAuthorship W2310073407A5046119070 @default.
• W2310073407 hasAuthorship W2310073407A5057200745 @default.
• W2310073407 hasAuthorship W2310073407A5059713499 @default.
• W2310073407 hasAuthorship W2310073407A5060602384 @default.
• W2310073407 hasConcept C104317684 @default.
• W2310073407 hasConcept C109825262 @default.
• W2310073407 hasConcept C121608353 @default.
• W2310073407 hasConcept C126322002 @default.
• W2310073407 hasConcept C13514818 @default.
• W2310073407 hasConcept C142724271 @default.
• W2310073407 hasConcept C143998085 @default.
• W2310073407 hasConcept C180754005 @default.
• W2310073407 hasConcept C2775894508 @default.
• W2310073407 hasConcept C2776559941 @default.
• W2310073407 hasConcept C2777428134 @default.
• W2310073407 hasConcept C2779767149 @default.
• W2310073407 hasConcept C501734568 @default.
• W2310073407 hasConcept C526805850 @default.
• W2310073407 hasConcept C54355233 @default.
• W2310073407 hasConcept C60748783 @default.
• W2310073407 hasConcept C61320498 @default.
• W2310073407 hasConcept C71924100 @default.
• W2310073407 hasConcept C86803240 @default.
• W2310073407 hasConcept C90924648 @default.
• W2310073407 hasConceptScore W2310073407C104317684 @default.
• W2310073407 hasConceptScore W2310073407C109825262 @default.
• W2310073407 hasConceptScore W2310073407C121608353 @default.
• W2310073407 hasConceptScore W2310073407C126322002 @default.
• W2310073407 hasConceptScore W2310073407C13514818 @default.
• W2310073407 hasConceptScore W2310073407C142724271 @default.
• W2310073407 hasConceptScore W2310073407C143998085 @default.
• W2310073407 hasConceptScore W2310073407C180754005 @default.
• W2310073407 hasConceptScore W2310073407C2775894508 @default.
• W2310073407 hasConceptScore W2310073407C2776559941 @default.
• W2310073407 hasConceptScore W2310073407C2777428134 @default.
• W2310073407 hasConceptScore W2310073407C2779767149 @default.
• W2310073407 hasConceptScore W2310073407C501734568 @default.
• W2310073407 hasConceptScore W2310073407C526805850 @default.

• next