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• W2310241738 abstract "This chapter describes the identification, function, and structure of the epidermal growth factor receptor (EGFR)/estrogen receptor B-1 (ErB-1). v- erbB is the oncogene of avian erythroblastosis virus (AEV), strain AEV-H, detected by hybridizing viral mRNA with cDNA made against the unique sequences of AEV. The EGFR family includes HER2/ErbB-2, HER3/Neu/ErbB-3, and HER4/ErbB-4. The EGFR can heterodimerize with each of the other members of the EGFR family and individual ligands for this family give rise to distinct patterns of trans-phosphorylation. EGF activates a second pathway which involves the rapid activation of latent cytoplasmic transcription factors called signal transducers and activators of transcription (STATs). EGF or amphiregulin causes the tyrosine phosphorylation of STAT1, STAT3, and STAT5, which mediates the activation of FOS through interaction with the serum-inducible element. It is found that expression of a dominant negative mutant of EGFR in the epidermis that suppresses autophosphorylation of endogenous EGFR causes marked alterations in hair follicle development and skin structure. It is observed that in v- erbB the receptor binding domain and 30 C-terminal residues are deleted and there are eight point mutations, relative to chicken EGFR." @default.
• W2310241738 created "2016-06-24" @default.
• W2310241738 creator A5039947845 @default.
• W2310241738 date "1997-01-01" @default.
• W2310241738 modified "2023-09-27" @default.
• W2310241738 title "EGFR/ErbB-1" @default.
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• W2310241738 doi "https://doi.org/10.1016/b978-012344548-3/50029-7" @default.
• W2310241738 hasPublicationYear "1997" @default.
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