Matches in SemOpenAlex for { <https://semopenalex.org/work/W2310322011> ?p ?o ?g. }
- W2310322011 endingPage "498" @default.
- W2310322011 startingPage "484" @default.
- W2310322011 abstract "Dynamic modulation of protein levels is tightly controlled in response to physiological cues. In mammalian cells, much of the protein degradation is carried out by the ubiquitin-proteasome system (UPS). Similar to kinases, components of the ubiquitin system are often dysregulated, leading to a variety of diseases, including cancer and neurodegeneration, making them attractive drug targets. However, so far there are only a handful of drugs targeting the ubiquitin system that have been approved by the FDA. Here, we review possible therapeutic intervention nodes in the ubiquitin system, analyze the challenges, and highlight the most promising strategies to target the UPS." @default.
- W2310322011 created "2016-06-24" @default.
- W2310322011 creator A5062624862 @default.
- W2310322011 creator A5084210146 @default.
- W2310322011 date "2016-03-22" @default.
- W2310322011 modified "2023-10-16" @default.
- W2310322011 title "Drugging the undruggables: exploring the ubiquitin system for drug development" @default.
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