FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2310367942> ?p ?o ?g. }

• W2310367942 endingPage "L775" @default.
• W2310367942 startingPage "L768" @default.
• W2310367942 abstract "Asthma is a chronic disease of the airways; asthma patients are hampered by recurrent symptoms of dyspnoea and wheezing caused by bronchial obstruction. Most asthma patients suffer from chronic allergic lung inflammation triggered by allergens such as house dust mite (HDM). Coagulation activation in the pulmonary compartment is currently recognized as a feature of allergic lung inflammation, and data suggest that coagulation proteases further drive inflammatory mechanisms. Here, we tested whether treatment with the oral thrombin inhibitor dabigatran attenuates allergic lung inflammation in a recently developed HDM-based murine asthma model. Mice were fed dabigatran (10 mg/g) or placebo chow during a 3-wk HDM airway exposure model. Dabigatran treatment caused systemic thrombin inhibitory activity corresponding with dabigatran levels reported in human trials. Surprisingly, dabigatran did not lead to inhibition of HDM-evoked coagulation activation in the lung as measured by levels of thrombin-antithrombin complexes and D-dimer. Repeated HDM administration caused an influx of eosinophils and neutrophils into the lungs, mucus production in the airways, and a T helper 2 response, as reflected by a rise in bronchoalveolar IL-4 and IL-5 levels and a systemic rise in IgE and HDM-IgG1. Dabigatran modestly improved HDM-induced lung pathology (P < 0.05) and decreased IL-4 levels (P < 0.01), without influencing other HDM-induced responses. Considering the limited effects of dabigatran in spite of adequate plasma levels, these results argue against clinical evaluation of dabigatran in patients with asthma." @default.
• W2310367942 created "2016-06-24" @default.
• W2310367942 creator A5001280693 @default.
• W2310367942 creator A5026410723 @default.
• W2310367942 creator A5042624694 @default.
• W2310367942 creator A5044893401 @default.
• W2310367942 creator A5048965254 @default.
• W2310367942 creator A5060943192 @default.
• W2310367942 creator A5067004234 @default.
• W2310367942 creator A5074830505 @default.
• W2310367942 creator A5091785748 @default.
• W2310367942 date "2015-10-15" @default.
• W2310367942 modified "2023-10-18" @default.
• W2310367942 title "Effect of the oral thrombin inhibitor dabigatran on allergic lung inflammation induced by repeated house dust mite administration in mice" @default.
• W2310367942 cites W1531871815 @default.
• W2310367942 cites W1683908058 @default.
• W2310367942 cites W1861812628 @default.
• W2310367942 cites W1976292850 @default.
• W2310367942 cites W1979861040 @default.
• W2310367942 cites W1992112980 @default.
• W2310367942 cites W1995511753 @default.
• W2310367942 cites W1995931298 @default.
• W2310367942 cites W2002364801 @default.
• W2310367942 cites W2013650052 @default.
• W2310367942 cites W2023506531 @default.
• W2310367942 cites W2034135112 @default.
• W2310367942 cites W2034575413 @default.
• W2310367942 cites W2054188263 @default.
• W2310367942 cites W2062228528 @default.
• W2310367942 cites W2064369146 @default.
• W2310367942 cites W2071326163 @default.
• W2310367942 cites W2074703520 @default.
• W2310367942 cites W2080285768 @default.
• W2310367942 cites W2080559678 @default.
• W2310367942 cites W2081375496 @default.
• W2310367942 cites W2099468529 @default.
• W2310367942 cites W2099959232 @default.
• W2310367942 cites W2112516075 @default.
• W2310367942 cites W2113446992 @default.
• W2310367942 cites W2117690071 @default.
• W2310367942 cites W2119803792 @default.
• W2310367942 cites W2142760318 @default.
• W2310367942 cites W2155345300 @default.
• W2310367942 cites W2156697078 @default.
• W2310367942 cites W2165427844 @default.
• W2310367942 cites W4211182003 @default.
• W2310367942 cites W4243168693 @default.
• W2310367942 cites W4250707920 @default.
• W2310367942 doi "https://doi.org/10.1152/ajplung.00102.2015" @default.
• W2310367942 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26320153" @default.
• W2310367942 hasPublicationYear "2015" @default.
• W2310367942 type Work @default.
• W2310367942 sameAs 2310367942 @default.
• W2310367942 citedByCount "7" @default.
• W2310367942 countsByYear W23103679422016 @default.
• W2310367942 countsByYear W23103679422017 @default.
• W2310367942 countsByYear W23103679422019 @default.
• W2310367942 countsByYear W23103679422020 @default.
• W2310367942 countsByYear W23103679422022 @default.
• W2310367942 crossrefType "journal-article" @default.
• W2310367942 hasAuthorship W2310367942A5001280693 @default.
• W2310367942 hasAuthorship W2310367942A5026410723 @default.
• W2310367942 hasAuthorship W2310367942A5042624694 @default.
• W2310367942 hasAuthorship W2310367942A5044893401 @default.
• W2310367942 hasAuthorship W2310367942A5048965254 @default.
• W2310367942 hasAuthorship W2310367942A5060943192 @default.
• W2310367942 hasAuthorship W2310367942A5067004234 @default.
• W2310367942 hasAuthorship W2310367942A5074830505 @default.
• W2310367942 hasAuthorship W2310367942A5091785748 @default.
• W2310367942 hasConcept C126322002 @default.
• W2310367942 hasConcept C203014093 @default.
• W2310367942 hasConcept C207480886 @default.
• W2310367942 hasConcept C2776042228 @default.
• W2310367942 hasConcept C2776301958 @default.
• W2310367942 hasConcept C2776914184 @default.
• W2310367942 hasConcept C2777714996 @default.
• W2310367942 hasConcept C2777961210 @default.
• W2310367942 hasConcept C2778166374 @default.
• W2310367942 hasConcept C2778382381 @default.
• W2310367942 hasConcept C2778810321 @default.
• W2310367942 hasConcept C2779161974 @default.
• W2310367942 hasConcept C2780510475 @default.
• W2310367942 hasConcept C71924100 @default.
• W2310367942 hasConceptScore W2310367942C126322002 @default.
• W2310367942 hasConceptScore W2310367942C203014093 @default.
• W2310367942 hasConceptScore W2310367942C207480886 @default.
• W2310367942 hasConceptScore W2310367942C2776042228 @default.
• W2310367942 hasConceptScore W2310367942C2776301958 @default.
• W2310367942 hasConceptScore W2310367942C2776914184 @default.
• W2310367942 hasConceptScore W2310367942C2777714996 @default.
• W2310367942 hasConceptScore W2310367942C2777961210 @default.
• W2310367942 hasConceptScore W2310367942C2778166374 @default.
• W2310367942 hasConceptScore W2310367942C2778382381 @default.
• W2310367942 hasConceptScore W2310367942C2778810321 @default.
• W2310367942 hasConceptScore W2310367942C2779161974 @default.
• W2310367942 hasConceptScore W2310367942C2780510475 @default.
• W2310367942 hasConceptScore W2310367942C71924100 @default.
• W2310367942 hasIssue "8" @default.

• next