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- W2310592009 abstract "The solution properties of human plasma apolipoprotein C-II (apoC-II) have been studied by analytical ultracentrifugation, circular dichroic spectroscopy, and fluorescence spectroscopy. ApoC-II self-associates in solution, even though no rigorous thermodynamic analysis of the mode of self-association could be established. The reversible denaturation of apoC-II by guanidinium chloride (GdmCl) proceeded in a sequential fashion. Initial disruption of protein self-association by 0.3 M GdmCl was followed by cooperative unfolding of monomeric protein at higher GdmCl concentratioans with a midpoint 1.1 M GdmCl. Based on tryptophan fluorescence quenching unfolded apoC-II was more permeable to penetration by small molecules than the self-associated protein. a very low free energy (delta GH2O = 2.8 kcal/mol) of denaturation was calculated from the GdmCl denaturation titration curve. Heating of apoC-II to 55 degrees C did not induce a reversible cooperative unfolding of the protein. Calculations, bsed on Chou-Fasman probability algorithms, reveal three sequential helical regions in apoC-II and one beta sheet structure (residues 61-74P. The locations of these regions are consistent with the known physiological functions of apoC-II." @default.
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- W2310592009 date "1980-09-01" @default.
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- W2310592009 title "The conformational properties of human plasma apolipoprotein C-II. A spectroscopic study." @default.
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- W2310592009 doi "https://doi.org/10.1016/s0021-9258(19)70628-0" @default.
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