Matches in SemOpenAlex for { <https://semopenalex.org/work/W2310765814> ?p ?o ?g. }
- W2310765814 endingPage "537" @default.
- W2310765814 startingPage "521" @default.
- W2310765814 abstract "The quest to improve the detection of biomolecules and cells in health and life sciences has led to the discovery and characterization of various affinity bioprobes. Libraries of synthetic oligonucleotides (ssDNA/ssRNA) with randomized sequences are employed during Systematic Evolution of Ligands by Exponential Enrichment (SELEX) to select highly specific affinity probes called aptamers. With much focus on the generation of aptamers for a variety of target molecules, conventional SELEX protocols have been modified to develop new and improved SELEX protocols yielding highly specific and stable aptamers. Various techniques have been used to analyze the binding interactions between aptamers and their cognate molecules with associated merits and limitations. This article comprehensively reviews research advancements in the generation of aptamers, analyses physicochemical conditions affecting their binding characteristics to cellular and biomolecular targets, and discusses various field applications of aptameric binding. Biophysical techniques employed in the characterization of the molecular and binding features of aptamers to their cognate targets are also discussed." @default.
- W2310765814 created "2016-06-24" @default.
- W2310765814 creator A5004176008 @default.
- W2310765814 creator A5038079943 @default.
- W2310765814 creator A5052731044 @default.
- W2310765814 creator A5057674473 @default.
- W2310765814 creator A5063961524 @default.
- W2310765814 creator A5065926170 @default.
- W2310765814 date "2016-03-15" @default.
- W2310765814 modified "2023-10-18" @default.
- W2310765814 title "SELEX Modifications and Bioanalytical Techniques for Aptamer–Target Binding Characterization" @default.
- W2310765814 cites W1621386139 @default.
- W2310765814 cites W1648483769 @default.
- W2310765814 cites W1942529712 @default.
- W2310765814 cites W1963659626 @default.
- W2310765814 cites W1964890218 @default.
- W2310765814 cites W1970825755 @default.
- W2310765814 cites W1971519164 @default.
- W2310765814 cites W1971583462 @default.
- W2310765814 cites W1971785970 @default.
- W2310765814 cites W1978419983 @default.
- W2310765814 cites W1979483334 @default.
- W2310765814 cites W1980177485 @default.
- W2310765814 cites W1985424766 @default.
- W2310765814 cites W1986515570 @default.
- W2310765814 cites W1986799612 @default.
- W2310765814 cites W1988021279 @default.
- W2310765814 cites W1990893433 @default.
- W2310765814 cites W1994649612 @default.
- W2310765814 cites W1995543320 @default.
- W2310765814 cites W1995857679 @default.
- W2310765814 cites W1996566248 @default.
- W2310765814 cites W1999599455 @default.
- W2310765814 cites W2001266427 @default.
- W2310765814 cites W2003451349 @default.
- W2310765814 cites W2004237137 @default.
- W2310765814 cites W2008974490 @default.
- W2310765814 cites W2009281456 @default.
- W2310765814 cites W2009910743 @default.
- W2310765814 cites W2010120270 @default.
- W2310765814 cites W2011554908 @default.
- W2310765814 cites W2013909252 @default.
- W2310765814 cites W2014941346 @default.
- W2310765814 cites W2017060659 @default.
- W2310765814 cites W2022022212 @default.
- W2310765814 cites W2023638011 @default.
- W2310765814 cites W2026482556 @default.
- W2310765814 cites W2032656060 @default.
- W2310765814 cites W2033145378 @default.
- W2310765814 cites W2034532181 @default.
- W2310765814 cites W2035509237 @default.
- W2310765814 cites W2035569644 @default.
- W2310765814 cites W2038495323 @default.
- W2310765814 cites W2038947027 @default.
- W2310765814 cites W2039483068 @default.
- W2310765814 cites W2039658297 @default.
- W2310765814 cites W2040376754 @default.
- W2310765814 cites W2041872811 @default.
- W2310765814 cites W2043137047 @default.
- W2310765814 cites W2043872789 @default.
- W2310765814 cites W2044601776 @default.
- W2310765814 cites W2044775131 @default.
- W2310765814 cites W2045051369 @default.
- W2310765814 cites W2051653724 @default.
- W2310765814 cites W2052130034 @default.
- W2310765814 cites W2054618173 @default.
- W2310765814 cites W2057518975 @default.
- W2310765814 cites W2058645840 @default.
- W2310765814 cites W2059281433 @default.
- W2310765814 cites W2059633563 @default.
- W2310765814 cites W2060955882 @default.
- W2310765814 cites W2062693976 @default.
- W2310765814 cites W2063915956 @default.
- W2310765814 cites W2065502281 @default.
- W2310765814 cites W2068715081 @default.
- W2310765814 cites W2072282398 @default.
- W2310765814 cites W2073170953 @default.
- W2310765814 cites W2079321730 @default.
- W2310765814 cites W2079450159 @default.
- W2310765814 cites W2081136588 @default.
- W2310765814 cites W2084373725 @default.
- W2310765814 cites W2088202442 @default.
- W2310765814 cites W2088267546 @default.
- W2310765814 cites W2090905113 @default.
- W2310765814 cites W2092818398 @default.
- W2310765814 cites W2095052940 @default.
- W2310765814 cites W2095984749 @default.
- W2310765814 cites W2096003356 @default.
- W2310765814 cites W2097545575 @default.
- W2310765814 cites W2098714223 @default.
- W2310765814 cites W2103052392 @default.
- W2310765814 cites W2104056258 @default.
- W2310765814 cites W2104525153 @default.
- W2310765814 cites W2104708861 @default.
- W2310765814 cites W2104721294 @default.
- W2310765814 cites W2109078461 @default.
- W2310765814 cites W2114783261 @default.
- W2310765814 cites W2116467487 @default.