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- W2310966659 endingPage "3752" @default.
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- W2310966659 abstract "Chromatin boundaries are architectural elements that determine the three-dimensional folding of the chromatin fiber and organize the chromosome into independent units of genetic activity. The Fab-7 boundary from the Drosophila bithorax complex (BX-C) is required for the parasegment-specific expression of the Abd-B gene. We have used a replacement strategy to identify sequences that are necessary and sufficient for Fab-7 boundary function in the BX-C. Fab-7 boundary activity is known to depend on factors that are stage specific, and we describe a novel ∼700-kDa complex, the late boundary complex (LBC), that binds to Fab-7 sequences that have insulator functions in late embryos and adults. We show that the LBC is enriched in nuclear extracts from late, but not early, embryos and that it contains three insulator proteins, GAF, Mod(mdg4), and E(y)2. Its DNA binding properties are unusual in that it requires a minimal sequence of >65 bp; however, other than a GAGA motif, the three Fab-7 LBC recognition elements display few sequence similarities. Finally, we show that mutations which abrogate LBC binding in vitro inactivate the Fab-7 boundary in the BX-C." @default.
- W2310966659 created "2016-06-24" @default.
- W2310966659 creator A5013501799 @default.
- W2310966659 creator A5016352223 @default.
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- W2310966659 creator A5049841678 @default.
- W2310966659 creator A5083361489 @default.
- W2310966659 creator A5084013728 @default.
- W2310966659 date "2015-11-01" @default.
- W2310966659 modified "2023-10-14" @default.
- W2310966659 title "Functional Requirements for <i>Fab-7</i> Boundary Activity in the Bithorax Complex" @default.
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