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- W2310987891 abstract "A rapid and sensitive ultra-high-performance liquid chromatography–quadrupole-time-of-flight mass spectrometric (UHPLC–Q-TOF-MS) method was developed for quantification of imipramine, one of the most widely used tricyclic antidepressants, and desipramine, an active metabolite of imipramine, in mouse serum. The developed method included a simple protein precipitation with acetonitrile in 50 μL of serum and analyte separation on an Acquity UPLC BEH C18 column using a gradient elution of acetonitrile with 0.1% formic acid and 20 mM ammonium formate. As a result, the entire analysis time was <20 min including the sample preparation and the LC–MS analysis. The limit of quantification was 5.0 ng mL−1 for both imipramine and desipramine, and calibration curves were linear over the concentration range of 5.0–1,000.0 and 5.0–250.0 ng mL−1 for imipramine and desipramine, respectively. Intraday precisions at three levels were 2.2–3.6 and 1.7–4.2% for imipramine and desipramine, respectively, whereas interday precisions were 2.6–5.0 and 2.0–8.4% for imipramine and desipramine, respectively. Accuracy ranged between 93.6 and 106.6% for imipramine and 94.1 and 106.4% for desipramine. Absolute recovery was 96.0–97.6% for imipramine and 87.0–99.5% for desipramine. Finally, the described method was applied to mice administered with imipramine, demonstrating the suitability for quantification of imipramine and desipramine for therapeutic drug monitoring or bioequivalence studies." @default.
- W2310987891 created "2016-06-24" @default.
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- W2310987891 date "2015-12-19" @default.
- W2310987891 modified "2023-10-18" @default.
- W2310987891 title "A Simple, Rapid and Reliable Method to Determine Imipramine and Desipramine in Mouse Serum Using Ultra-High-Performance Liquid Chromatography–Quadrupole-Time-of-Flight Mass Spectrometry" @default.
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- W2310987891 doi "https://doi.org/10.1093/chromsci/bmv187" @default.
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