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• W2311315420 abstract "La enfermedad de Crohn (EC) es un trastorno inflamatorio crónico del tubo digestivo, de etiología desconocida, que puede afectar a cualquier segmento del mismo, desde la boca hasta el ano. La EC tiene un curso crónico, recidivante, pudiendo aparecer complicaciones tales como estenosis o fístulas a lo largo de su evolución. En la actualidad, no se dispone de un tratamiento curativo para esta enfermedad, por lo que el objetivo terapéutico se limita al control de la actividad inflamatoria para prevenir la aparición de complicaciones y que el paciente pueda disfrutar de una buena calidad de vida. Los esteroides, los inmunosupresores (tiopurinas y metotrexato) y los fármacos biológicos (infliximab, adalimumab y vedolizumab) han demostrado ser eficaces en el tratamiento de la EC. No obstante, una proporción relevante de pacientes será refractaria a estos tratamientos o perderá respuesta a lo largo del tiempo, por lo que, finalmente, muchos deberán someterse a cirugía. El tratamiento quirúrgico no es curativo en la EC, por lo que, en ausencia de un tratamiento preventivo eficaz, la recidiva será la norma. Crohn's disease (CD) is a chronic inflammatory disorder of the digestive tract of unknown etiology, which can affect any segment thereof, from the mouth to the anus. The CD has a chronic, relapsing course, complications such as stenosis or fistulas along its evolution may appear. Currently, there are no curative treatment for this disease, so the therapeutic objective is limited to the control of inflammatory activity to prevent the onset of complications and the patient can enjoy a good quality of life. Steroids, immunosuppressants (thiopurines and methotrexate) and biologic agents (infliximab, adalimumab and vedolizumab) have proven effective in the treatment of CD. However, a significant proportion of patients will be refractory to these treatments or lose response over time, so that ultimately many will undergo surgery. Surgical treatment is not curative in CD, so that in the absence of an effective preventive treatment, relapse is the norm." @default.
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• W2311315420 date "2016-03-01" @default.
• W2311315420 modified "2023-09-27" @default.
• W2311315420 title "Actualización del diagnóstico y tratamiento de la enfermedad de Crohn" @default.
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• W2311315420 doi "https://doi.org/10.1016/j.med.2016.02.018" @default.
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