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- W2311367195 abstract "The transcription factor STAT5 is fundamental to the mammalian immune system. However, the relationship between its two paralogs, STAT5A and STAT5B, and the extent to which they are functionally distinct, remain uncertain. Using mouse models of paralog deficiency, we demonstrate that they are not equivalent for CD4+ 'helper' T cells, the principal orchestrators of adaptive immunity. Instead, we find that STAT5B is dominant for both effector and regulatory (Treg) responses and, therefore, uniquely necessary for immunological tolerance. Comparative analysis of genomic distribution and transcriptomic output confirm that STAT5B has fargreater impact but, surprisingly, the data point towards asymmetric expression (i.e. paralog dose), rather than distinct functional properties, as the key distinguishing feature. Thus, we propose a quantitative model of STAT5 paralog activity whereby relative abundance imposes functional specificity (or dominance) in the face of widespread structural homology." @default.
- W2311367195 created "2016-06-24" @default.
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- W2311367195 date "2016-03-21" @default.
- W2311367195 modified "2023-09-29" @default.
- W2311367195 title "Signal transducer and activator of transcription 5 (STAT5) paralog dose governs T cell effector and regulatory functions" @default.
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- W2311367195 doi "https://doi.org/10.7554/elife.08384" @default.
- W2311367195 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4856466" @default.
- W2311367195 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26999798" @default.
- W2311367195 hasPublicationYear "2016" @default.
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