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• W2311406601 abstract "The intracellular pathogen Shigella flexneri is the causative agent of bacillary dysentery in humans. The disease is characterized by bacterial invasion of intestinal cells, dissemination within the colonic epithelium through direct spread from cell to cell, and massive inflammation of the intestinal mucosa. Here, we review the mechanisms supporting S. flexneri dissemination. The dissemination process primarily relies on actin assembly at the bacterial pole, which propels the pathogen throughout the cytosol of primary infected cells. Polar actin assembly is supported by polar expression of the bacterial autotransporter family member IcsA, which recruits the N-WASP/ARP2/3 actin assembly machinery. As motile bacteria encounter cell-cell contacts, they form plasma membrane protrusions that project into adjacent cells. In addition to the ARP2/3-dependent actin assembly machinery, protrusion formation relies on formins and myosins. The resolution of protrusions into vacuoles occurs through the collapse of the protrusion neck, leading to the formation of an intermediate membrane-bound compartment termed vacuole-like protrusions (VLPs). VLP formation requires tyrosine kinase and phosphoinositide signaling in protrusions, which relies on the integrity of the bacterial type 3 secretion system (T3SS). The T3SS is also required for escaping double membrane vacuoles through the activity of the T3SS translocases IpaB and IpaC, and the effector proteins VirA and IcsB. Numerous factors supporting envelope biogenesis contribute to IcsA exposure and maintenance at the bacterial pole, including LPS synthesis, membrane proteases, and periplasmic chaperones. Although less characterized, the assembly and function of the T3SS in the context of bacterial dissemination also relies on factors supporting envelope biogenesis. Finally, the dissemination process requires the adaptation of the pathogen to various cellular compartments through transcriptional and post-transcriptional mechanisms." @default.
• W2311406601 created "2016-06-24" @default.
• W2311406601 creator A5077876704 @default.
• W2311406601 date "2016-03-11" @default.
• W2311406601 modified "2023-10-06" @default.
• W2311406601 title "Molecular and Cellular Mechanisms of Shigella flexneri Dissemination" @default.
• W2311406601 cites W1486582546 @default.
• W2311406601 cites W1495239180 @default.
• W2311406601 cites W1495841186 @default.
• W2311406601 cites W1583038199 @default.
• W2311406601 cites W1593929303 @default.
• W2311406601 cites W1892326398 @default.
• W2311406601 cites W1947325587 @default.
• W2311406601 cites W1949828943 @default.
• W2311406601 cites W1965841929 @default.
• W2311406601 cites W1966183474 @default.
• W2311406601 cites W1969556092 @default.
• W2311406601 cites W1972515246 @default.
• W2311406601 cites W1978751572 @default.
• W2311406601 cites W1980131133 @default.
• W2311406601 cites W1986480819 @default.
• W2311406601 cites W1987706049 @default.
• W2311406601 cites W1988282769 @default.
• W2311406601 cites W1992316183 @default.
• W2311406601 cites W1995686748 @default.
• W2311406601 cites W1998990979 @default.
• W2311406601 cites W2008569641 @default.
• W2311406601 cites W2008850485 @default.
• W2311406601 cites W2009508814 @default.
• W2311406601 cites W2010001605 @default.
• W2311406601 cites W2010378362 @default.
• W2311406601 cites W2014696847 @default.
• W2311406601 cites W2018910670 @default.
• W2311406601 cites W2027484213 @default.
• W2311406601 cites W2032208806 @default.
• W2311406601 cites W2034353085 @default.
• W2311406601 cites W2035308327 @default.
• W2311406601 cites W2040922306 @default.
• W2311406601 cites W2047136221 @default.
• W2311406601 cites W2056922902 @default.
• W2311406601 cites W2057201236 @default.
• W2311406601 cites W2059161447 @default.
• W2311406601 cites W2065259652 @default.
• W2311406601 cites W2067215670 @default.
• W2311406601 cites W2068758215 @default.
• W2311406601 cites W2069639612 @default.
• W2311406601 cites W2071513881 @default.
• W2311406601 cites W2074769891 @default.
• W2311406601 cites W2075982084 @default.
• W2311406601 cites W2077874976 @default.
• W2311406601 cites W2079098672 @default.
• W2311406601 cites W2081644840 @default.
• W2311406601 cites W2086490962 @default.
• W2311406601 cites W2087268191 @default.
• W2311406601 cites W2091425339 @default.
• W2311406601 cites W2100438695 @default.
• W2311406601 cites W2101523998 @default.
• W2311406601 cites W2107625881 @default.
• W2311406601 cites W2110640625 @default.
• W2311406601 cites W2110895797 @default.
• W2311406601 cites W2111006730 @default.
• W2311406601 cites W2112174530 @default.
• W2311406601 cites W2112659088 @default.
• W2311406601 cites W2114801075 @default.
• W2311406601 cites W2115772415 @default.
• W2311406601 cites W2116739864 @default.
• W2311406601 cites W2118036844 @default.
• W2311406601 cites W2128616172 @default.
• W2311406601 cites W2131241933 @default.
• W2311406601 cites W2134341850 @default.
• W2311406601 cites W2135449289 @default.
• W2311406601 cites W2135744145 @default.
• W2311406601 cites W2138417709 @default.
• W2311406601 cites W2140237288 @default.
• W2311406601 cites W2141848152 @default.
• W2311406601 cites W2144356386 @default.
• W2311406601 cites W2148334175 @default.
• W2311406601 cites W2148512633 @default.
• W2311406601 cites W2150220143 @default.
• W2311406601 cites W2154460798 @default.
• W2311406601 cites W2155196333 @default.
• W2311406601 cites W2157979667 @default.
• W2311406601 cites W2158903248 @default.
• W2311406601 cites W2159173712 @default.
• W2311406601 cites W2160791031 @default.
• W2311406601 cites W2164640625 @default.
• W2311406601 cites W2169060424 @default.
• W2311406601 cites W2170052693 @default.
• W2311406601 cites W2170447047 @default.
• W2311406601 cites W2170996392 @default.
• W2311406601 cites W2172275102 @default.
• W2311406601 cites W2181476743 @default.
• W2311406601 cites W2267790100 @default.
• W2311406601 cites W2317670854 @default.
• W2311406601 cites W4211218212 @default.
• W2311406601 cites W4237350771 @default.
• W2311406601 doi "https://doi.org/10.3389/fcimb.2016.00029" @default.
• W2311406601 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4786538" @default.
• W2311406601 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27014639" @default.
• W2311406601 hasPublicationYear "2016" @default.

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