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- W2311471965 abstract "Alzheimer’s disease is a central nervous system (CNS) degenerative diseases. Amyloid β-peptide (Aβ42) is strongly responsible for the occurrence and development of Alzheimer’s disease(AD). Aβ42 peptide is resulted from the sequential proteoiytic cleavages of amyloid precursor protein (APP) by β-and γ-secretases. γ-secretase is a protease complex, and presenilin (PS) is the catalytic component of γ-secretase complex. Therefore, inhibition of PS or γ-secretase activity is the most effective way to treat AD, accordingly, PS or γ-secretase became a major target for AD treatment. Based on these thoughts, some methods of treating AD are put forward, and the inhibitors and regulators of PS or γ-secretase activity are becoming the focus of attention for the treatment of Alzheimer’s disease in recent years." @default.
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- W2311471965 date "2009-01-01" @default.
- W2311471965 modified "2023-10-03" @default.
- W2311471965 title "Inhibitor and regulator of presenilin for Alzheimer’s disease" @default.
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