FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2311620404> ?p ?o ?g. }

• W2311620404 endingPage "e0150192" @default.
• W2311620404 startingPage "e0150192" @default.
• W2311620404 abstract "Myotonic dystrophy type 1 (DM1), the most common form of muscular dystrophy in adults, is caused by toxic RNAs produced from the mutant DM protein kinase (DMPK) gene. DM1 is characterized by progressive muscle wasting and weakness. Therapeutic strategies have mainly focused on targeting the toxic RNA. Previously, we found that fibroblast growth factor-inducible 14 (Fn14), the receptor for TWEAK, is induced in skeletal muscles and hearts of mouse models of RNA toxicity and that blocking TWEAK/Fn14 signaling improves muscle function and histology. Here, we studied the effect of Tweak deficiency in a RNA toxicity mouse model. The genetic deletion of Tweak in these mice significantly reduced muscle damage and improved muscle function. In contrast, administration of TWEAK in the RNA toxicity mice impaired functional outcomes and worsened muscle histopathology. These studies show that signaling via TWEAK is deleterious to muscle in RNA toxicity and support the demonstrated utility of anti-TWEAK therapeutics." @default.
• W2311620404 created "2016-06-24" @default.
• W2311620404 creator A5020862162 @default.
• W2311620404 creator A5021811284 @default.
• W2311620404 creator A5039020483 @default.
• W2311620404 creator A5049845140 @default.
• W2311620404 creator A5050612637 @default.
• W2311620404 creator A5074577650 @default.
• W2311620404 date "2016-02-22" @default.
• W2311620404 modified "2023-10-11" @default.
• W2311620404 title "TWEAK Regulates Muscle Functions in a Mouse Model of RNA Toxicity" @default.
• W2311620404 cites W1547549972 @default.
• W2311620404 cites W1568796088 @default.
• W2311620404 cites W1964008557 @default.
• W2311620404 cites W1975652448 @default.
• W2311620404 cites W1980677946 @default.
• W2311620404 cites W1982753466 @default.
• W2311620404 cites W1983159021 @default.
• W2311620404 cites W2009769042 @default.
• W2311620404 cites W2019905182 @default.
• W2311620404 cites W2022313401 @default.
• W2311620404 cites W2025855695 @default.
• W2311620404 cites W2048359227 @default.
• W2311620404 cites W2056222248 @default.
• W2311620404 cites W2058724969 @default.
• W2311620404 cites W2062031166 @default.
• W2311620404 cites W2062462227 @default.
• W2311620404 cites W2063881294 @default.
• W2311620404 cites W2068477500 @default.
• W2311620404 cites W2068839290 @default.
• W2311620404 cites W2076324093 @default.
• W2311620404 cites W2078217107 @default.
• W2311620404 cites W2081748748 @default.
• W2311620404 cites W2095854326 @default.
• W2311620404 cites W2100603424 @default.
• W2311620404 cites W2116911713 @default.
• W2311620404 cites W2126569475 @default.
• W2311620404 cites W2127814666 @default.
• W2311620404 cites W2128578017 @default.
• W2311620404 cites W2131948930 @default.
• W2311620404 cites W2138887185 @default.
• W2311620404 cites W2153445234 @default.
• W2311620404 cites W2162153647 @default.
• W2311620404 cites W2167935306 @default.
• W2311620404 cites W89028915 @default.
• W2311620404 doi "https://doi.org/10.1371/journal.pone.0150192" @default.
• W2311620404 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4762946" @default.
• W2311620404 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26901467" @default.
• W2311620404 hasPublicationYear "2016" @default.
• W2311620404 type Work @default.
• W2311620404 sameAs 2311620404 @default.
• W2311620404 citedByCount "6" @default.
• W2311620404 countsByYear W23116204042018 @default.
• W2311620404 countsByYear W23116204042020 @default.
• W2311620404 countsByYear W23116204042021 @default.
• W2311620404 countsByYear W23116204042022 @default.
• W2311620404 countsByYear W23116204042023 @default.
• W2311620404 crossrefType "journal-article" @default.
• W2311620404 hasAuthorship W2311620404A5020862162 @default.
• W2311620404 hasAuthorship W2311620404A5021811284 @default.
• W2311620404 hasAuthorship W2311620404A5039020483 @default.
• W2311620404 hasAuthorship W2311620404A5049845140 @default.
• W2311620404 hasAuthorship W2311620404A5050612637 @default.
• W2311620404 hasAuthorship W2311620404A5074577650 @default.
• W2311620404 hasBestOaLocation W23116204041 @default.
• W2311620404 hasConcept C102230213 @default.
• W2311620404 hasConcept C104317684 @default.
• W2311620404 hasConcept C105702510 @default.
• W2311620404 hasConcept C126322002 @default.
• W2311620404 hasConcept C134018914 @default.
• W2311620404 hasConcept C2776418732 @default.
• W2311620404 hasConcept C2778063965 @default.
• W2311620404 hasConcept C2779030066 @default.
• W2311620404 hasConcept C2779959927 @default.
• W2311620404 hasConcept C29730261 @default.
• W2311620404 hasConcept C54355233 @default.
• W2311620404 hasConcept C55493867 @default.
• W2311620404 hasConcept C67705224 @default.
• W2311620404 hasConcept C71924100 @default.
• W2311620404 hasConcept C86803240 @default.
• W2311620404 hasConcept C95444343 @default.
• W2311620404 hasConceptScore W2311620404C102230213 @default.
• W2311620404 hasConceptScore W2311620404C104317684 @default.
• W2311620404 hasConceptScore W2311620404C105702510 @default.
• W2311620404 hasConceptScore W2311620404C126322002 @default.
• W2311620404 hasConceptScore W2311620404C134018914 @default.
• W2311620404 hasConceptScore W2311620404C2776418732 @default.
• W2311620404 hasConceptScore W2311620404C2778063965 @default.
• W2311620404 hasConceptScore W2311620404C2779030066 @default.
• W2311620404 hasConceptScore W2311620404C2779959927 @default.
• W2311620404 hasConceptScore W2311620404C29730261 @default.
• W2311620404 hasConceptScore W2311620404C54355233 @default.
• W2311620404 hasConceptScore W2311620404C55493867 @default.
• W2311620404 hasConceptScore W2311620404C67705224 @default.
• W2311620404 hasConceptScore W2311620404C71924100 @default.
• W2311620404 hasConceptScore W2311620404C86803240 @default.
• W2311620404 hasConceptScore W2311620404C95444343 @default.
• W2311620404 hasIssue "2" @default.

• next