Matches in SemOpenAlex for { <https://semopenalex.org/work/W2311930432> ?p ?o ?g. }
- W2311930432 endingPage "65" @default.
- W2311930432 startingPage "57" @default.
- W2311930432 abstract "<b><i>Background:</i></b> With regard to acute stroke, patients with unknown time from stroke onset are not eligible for thrombolysis. Quantitative diffusion weighted imaging (DWI) and fluid attenuated inversion recovery (FLAIR) MRI relative signal intensity (rSI) biomarkers have been introduced to predict eligibility for thrombolysis, but have shown heterogeneous results in the past. In the present work, we investigated whether the inclusion of easily obtainable clinical-radiological parameters would improve the prediction of the thrombolysis time window by rSIs and compared their performance to the visual DWI-FLAIR mismatch. <b><i>Methods:</i></b> In a retrospective study, patients from 2 centers with proven stroke with onset <12 h were included. The DWI lesion was segmented and overlaid on ADC and FLAIR images. rSI mean and SD, were calculated as follows: (mean ROI value/mean value of the unaffected hemisphere). Additionally, the visual DWI-FLAIR mismatch was evaluated. Prediction of the thrombolysis time window was evaluated by the area-under-the-curve (AUC) derived from receiver operating characteristic (ROC) curve analysis. Factors such as the association of age, National Institutes of Health Stroke Scale, MRI field strength, lesion size, vessel occlusion and Wahlund-Score with rSI were investigated and the models were adjusted and stratified accordingly. <b><i>Results:</i></b> In 82 patients, the unadjusted rSI measures DWI-mean and -SD showed the highest AUCs (AUC 0.86-0.87). Adjustment for clinical-radiological covariates significantly improved the performance of FLAIR-mean (0.91) and DWI-SD (0.91). The best prediction results based on the AUC were found for the final stratified and adjusted models of DWI-SD (0.94) and FLAIR-mean (0.96) and a multivariable DWI-FLAIR model (0.95). The adjusted visual DWI-FLAIR mismatch did not perform in a significantly worse manner (0.89). ADC-rSIs showed fair performance in all models. <b><i>Conclusions:</i></b> Quantitative DWI and FLAIR MRI biomarkers as well as the visual DWI-FLAIR mismatch provide excellent prediction of eligibility for thrombolysis in acute stroke, when easily obtainable clinical-radiological parameters are included in the prediction models." @default.
- W2311930432 created "2016-06-24" @default.
- W2311930432 creator A5000965009 @default.
- W2311930432 creator A5014279977 @default.
- W2311930432 creator A5034245764 @default.
- W2311930432 creator A5034493341 @default.
- W2311930432 creator A5037167054 @default.
- W2311930432 creator A5040363812 @default.
- W2311930432 creator A5041512354 @default.
- W2311930432 creator A5055301518 @default.
- W2311930432 creator A5069274834 @default.
- W2311930432 creator A5074742815 @default.
- W2311930432 creator A5087508465 @default.
- W2311930432 creator A5088140610 @default.
- W2311930432 creator A5088743625 @default.
- W2311930432 creator A5090964646 @default.
- W2311930432 date "2016-01-01" @default.
- W2311930432 modified "2023-10-18" @default.
- W2311930432 title "Clinical-Radiological Parameters Improve the Prediction of the Thrombolysis Time Window by Both MRI Signal Intensities and DWI-FLAIR Mismatch" @default.
- W2311930432 cites W1505527646 @default.
- W2311930432 cites W1979483144 @default.
- W2311930432 cites W2003499625 @default.
- W2311930432 cites W2010435751 @default.
- W2311930432 cites W2017962682 @default.
- W2311930432 cites W2020624586 @default.
- W2311930432 cites W2065378454 @default.
- W2311930432 cites W2067747284 @default.
- W2311930432 cites W2093020037 @default.
- W2311930432 cites W2098329778 @default.
- W2311930432 cites W2104657667 @default.
- W2311930432 cites W2105902812 @default.
- W2311930432 cites W2111241951 @default.
- W2311930432 cites W2152023347 @default.
- W2311930432 cites W2165882703 @default.
- W2311930432 cites W2170593232 @default.
- W2311930432 cites W2328176404 @default.
- W2311930432 cites W2594075545 @default.
- W2311930432 doi "https://doi.org/10.1159/000444887" @default.
- W2311930432 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26986943" @default.
- W2311930432 hasPublicationYear "2016" @default.
- W2311930432 type Work @default.
- W2311930432 sameAs 2311930432 @default.
- W2311930432 citedByCount "11" @default.
- W2311930432 countsByYear W23119304322016 @default.
- W2311930432 countsByYear W23119304322017 @default.
- W2311930432 countsByYear W23119304322018 @default.
- W2311930432 countsByYear W23119304322019 @default.
- W2311930432 countsByYear W23119304322020 @default.
- W2311930432 countsByYear W23119304322021 @default.
- W2311930432 countsByYear W23119304322022 @default.
- W2311930432 countsByYear W23119304322023 @default.
- W2311930432 crossrefType "journal-article" @default.
- W2311930432 hasAuthorship W2311930432A5000965009 @default.
- W2311930432 hasAuthorship W2311930432A5014279977 @default.
- W2311930432 hasAuthorship W2311930432A5034245764 @default.
- W2311930432 hasAuthorship W2311930432A5034493341 @default.
- W2311930432 hasAuthorship W2311930432A5037167054 @default.
- W2311930432 hasAuthorship W2311930432A5040363812 @default.
- W2311930432 hasAuthorship W2311930432A5041512354 @default.
- W2311930432 hasAuthorship W2311930432A5055301518 @default.
- W2311930432 hasAuthorship W2311930432A5069274834 @default.
- W2311930432 hasAuthorship W2311930432A5074742815 @default.
- W2311930432 hasAuthorship W2311930432A5087508465 @default.
- W2311930432 hasAuthorship W2311930432A5088140610 @default.
- W2311930432 hasAuthorship W2311930432A5088743625 @default.
- W2311930432 hasAuthorship W2311930432A5090964646 @default.
- W2311930432 hasConcept C101070640 @default.
- W2311930432 hasConcept C126322002 @default.
- W2311930432 hasConcept C126838900 @default.
- W2311930432 hasConcept C127413603 @default.
- W2311930432 hasConcept C143409427 @default.
- W2311930432 hasConcept C146638467 @default.
- W2311930432 hasConcept C2779581417 @default.
- W2311930432 hasConcept C2780645631 @default.
- W2311930432 hasConcept C2989005 @default.
- W2311930432 hasConcept C500558357 @default.
- W2311930432 hasConcept C58471807 @default.
- W2311930432 hasConcept C71924100 @default.
- W2311930432 hasConcept C76318530 @default.
- W2311930432 hasConcept C78519656 @default.
- W2311930432 hasConceptScore W2311930432C101070640 @default.
- W2311930432 hasConceptScore W2311930432C126322002 @default.
- W2311930432 hasConceptScore W2311930432C126838900 @default.
- W2311930432 hasConceptScore W2311930432C127413603 @default.
- W2311930432 hasConceptScore W2311930432C143409427 @default.
- W2311930432 hasConceptScore W2311930432C146638467 @default.
- W2311930432 hasConceptScore W2311930432C2779581417 @default.
- W2311930432 hasConceptScore W2311930432C2780645631 @default.
- W2311930432 hasConceptScore W2311930432C2989005 @default.
- W2311930432 hasConceptScore W2311930432C500558357 @default.
- W2311930432 hasConceptScore W2311930432C58471807 @default.
- W2311930432 hasConceptScore W2311930432C71924100 @default.
- W2311930432 hasConceptScore W2311930432C76318530 @default.
- W2311930432 hasConceptScore W2311930432C78519656 @default.
- W2311930432 hasIssue "1-2" @default.
- W2311930432 hasLocation W23119304321 @default.
- W2311930432 hasLocation W23119304322 @default.
- W2311930432 hasOpenAccess W2311930432 @default.