Matches in SemOpenAlex for { <https://semopenalex.org/work/W2312201972> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W2312201972 abstract "Photodynamic therapy (PDT) is a promising treatment option for cancer. It can be used for drug-resistant andinoperable tumors. However, one of the unsolved problems in PDT is tumor recurrence. The aim of this study is tosuppress tumor regrowth by including angiogenesis inhibitors that target vascular endothelial growth factor (VEGF)and epidermal growth factor receptor (EGFR) pathways, to the PDT protocol. Human bladder cancer (MGH cellline) xenografts were induced in Balb/c nude mice. The animals treated with PDT received an intravenous injectionof hypericin followed by irradiation after 6 hours, with a broadband light source through a 560-640 NM bandpassfilter. A light dosage of 120 J/cm2 and 100 mW/cm2 was administered. Angiogenesis inhibitors, bevacizumaband cetuximab were administered at a dose of 10 mg/kg. Treatment efficacy was assessed by monitoring thetumor growth inhibition of xenograft tumors. Immunohistochemistry was performed to evaluate the expressionof VEGF and EGFR. Expression of the major proteins in the VEGF and EGFR pathways was investigated byimmunoblotting. One-way ANOVA with Bonferroni correction was performed to analyze the data. Tumors treatedwith the combination of PDT and inhibitors exhibited significantly greater treatment response compared to controland PDT groups. Downregulation of VEGF and EGFR observed in tumors treated with PDT + bevacizumaband cetuximab respectively. Our results show that blocking VEGF or/and EGFR pathways along with PDT caneffectively suppress tumor growth." @default.
- W2312201972 created "2016-06-24" @default.
- W2312201972 creator A5040948763 @default.
- W2312201972 creator A5060986238 @default.
- W2312201972 creator A5064730811 @default.
- W2312201972 creator A5067587535 @default.
- W2312201972 creator A5073618409 @default.
- W2312201972 date "2013-01-01" @default.
- W2312201972 modified "2023-10-01" @default.
- W2312201972 title "Combined use of Anti-VEGF and Anti-EGFR Monoclonal Antibodies with Photodynamic Therapy Suppresses Tumor Growth in an In vivo Tumor Model" @default.
- W2312201972 doi "https://doi.org/10.4172/1948-5956.1000192" @default.
- W2312201972 hasPublicationYear "2013" @default.
- W2312201972 type Work @default.
- W2312201972 sameAs 2312201972 @default.
- W2312201972 citedByCount "5" @default.
- W2312201972 countsByYear W23122019722015 @default.
- W2312201972 countsByYear W23122019722016 @default.
- W2312201972 countsByYear W23122019722023 @default.
- W2312201972 crossrefType "journal-article" @default.
- W2312201972 hasAuthorship W2312201972A5040948763 @default.
- W2312201972 hasAuthorship W2312201972A5060986238 @default.
- W2312201972 hasAuthorship W2312201972A5064730811 @default.
- W2312201972 hasAuthorship W2312201972A5067587535 @default.
- W2312201972 hasAuthorship W2312201972A5073618409 @default.
- W2312201972 hasBestOaLocation W23122019721 @default.
- W2312201972 hasConcept C150903083 @default.
- W2312201972 hasConcept C159654299 @default.
- W2312201972 hasConcept C163864487 @default.
- W2312201972 hasConcept C167734588 @default.
- W2312201972 hasConcept C178790620 @default.
- W2312201972 hasConcept C185592680 @default.
- W2312201972 hasConcept C203014093 @default.
- W2312201972 hasConcept C207001950 @default.
- W2312201972 hasConcept C2781323092 @default.
- W2312201972 hasConcept C502942594 @default.
- W2312201972 hasConcept C542903549 @default.
- W2312201972 hasConcept C71924100 @default.
- W2312201972 hasConcept C86803240 @default.
- W2312201972 hasConcept C98274493 @default.
- W2312201972 hasConceptScore W2312201972C150903083 @default.
- W2312201972 hasConceptScore W2312201972C159654299 @default.
- W2312201972 hasConceptScore W2312201972C163864487 @default.
- W2312201972 hasConceptScore W2312201972C167734588 @default.
- W2312201972 hasConceptScore W2312201972C178790620 @default.
- W2312201972 hasConceptScore W2312201972C185592680 @default.
- W2312201972 hasConceptScore W2312201972C203014093 @default.
- W2312201972 hasConceptScore W2312201972C207001950 @default.
- W2312201972 hasConceptScore W2312201972C2781323092 @default.
- W2312201972 hasConceptScore W2312201972C502942594 @default.
- W2312201972 hasConceptScore W2312201972C542903549 @default.
- W2312201972 hasConceptScore W2312201972C71924100 @default.
- W2312201972 hasConceptScore W2312201972C86803240 @default.
- W2312201972 hasConceptScore W2312201972C98274493 @default.
- W2312201972 hasIssue "03" @default.
- W2312201972 hasLocation W23122019721 @default.
- W2312201972 hasOpenAccess W2312201972 @default.
- W2312201972 hasPrimaryLocation W23122019721 @default.
- W2312201972 hasRelatedWork W1971294201 @default.
- W2312201972 hasRelatedWork W1999686187 @default.
- W2312201972 hasRelatedWork W2025678534 @default.
- W2312201972 hasRelatedWork W2036403810 @default.
- W2312201972 hasRelatedWork W2073840950 @default.
- W2312201972 hasRelatedWork W2146940419 @default.
- W2312201972 hasRelatedWork W2163154638 @default.
- W2312201972 hasRelatedWork W2366047017 @default.
- W2312201972 hasRelatedWork W2766139987 @default.
- W2312201972 hasRelatedWork W4298901412 @default.
- W2312201972 hasVolume "05" @default.
- W2312201972 isParatext "false" @default.
- W2312201972 isRetracted "false" @default.
- W2312201972 magId "2312201972" @default.
- W2312201972 workType "article" @default.