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- W2312225904 abstract "A concise and stereoselective total synthesis of (−)-salinosporamide A (1), a potent inhibitor of the 20S proteasome that is in clinical development as an anticancer drug candidate, has been accomplished in 14 steps with 19% overall yield from 4-pentenoic acid. Our synthesis features a stereoselective alkylation utilizing a chiral auxiliary, formation of a pyrrolidine unit, and oxidation of the pyrrolidine to a γ-lactam. To demonstrate the scalability of our synthesis, (−)-salinosporamide A has been synthesized on a gram scale." @default.
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- W2312225904 date "2011-05-17" @default.
- W2312225904 modified "2023-10-01" @default.
- W2312225904 title "Total Synthesis of (−)-Salinosporamide A" @default.
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- W2312225904 doi "https://doi.org/10.1021/ol200886j" @default.
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