FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2312252295> ?p ?o ?g. }

• W2312252295 endingPage "e732" @default.
• W2312252295 startingPage "e732" @default.
• W2312252295 abstract "Chronic myeloproliferative disorders such as polycythemia vera (PV), essential thrombocytosis (ET), and idiopathic myelofibrosis arise from clonal proliferation of neoplastic stem cells in the bone marrow. Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that have potential to degrade all types of extracellular matrix (ECM) and also play a role in remodeling of the ECM. It is known that MMPs play a role in bone marrow remodeling. The primary goal of our study is to explore the relationship between chronic myeloproliferative diseases and some of MMP gene polymorphisms. The demonstration of a relationship will help to understand whether these polymorphisms may be a potential early diagnosis marker of the diseases. Patients were selected from outpatient clinics of Turgut Ozal University Hospital, Ankara, Turkey, between December 2010 and May 2011. Twenty-eight patients that previously diagnosed and followed-up with PV, 17 with secondary polycythemia (SP), and 12 with ET were enrolled in the study, along with a control group of 22 healthy people. DNA was isolated from peripheral blood. Using polymerase chain reaction–restriction fragment length polymorphism method, MMP2 and MMP9 gene polymorphisms were analyzed with agarose gel electrophoresis. There was a statistically significant difference between the study groups and the control group in terms of Gln279Arg polymorphisms rates of MMP9. The highest MMP9 Gln279Arg polymorphism rate was observed in the ET group. But nobody from the control group had polymorphic MMP9. There was no statistically significant difference between the groups in terms of MMP2-735 C > T polymorphism rates. In conclusion, MMP9 gene Gln279Arg polymorphism was associated with ET, SP, and PV diseases. Hence, we believe that these gene polymorphisms may play a role in the mechanism of bone marrow fibrosis and may be a factor that increases the risk of thrombosis. Illumination of the molecular basis of the relationship between MMP-thrombosis and MMP-fibrosis provides a better understanding of the pathophysiology of PV and ET diseases and will allow new approaches to diagnosis and treatment." @default.
• W2312252295 created "2016-06-24" @default.
• W2312252295 creator A5004097738 @default.
• W2312252295 creator A5013902236 @default.
• W2312252295 creator A5014590544 @default.
• W2312252295 creator A5038885635 @default.
• W2312252295 creator A5051162121 @default.
• W2312252295 creator A5057279608 @default.
• W2312252295 creator A5075525060 @default.
• W2312252295 creator A5075937522 @default.
• W2312252295 creator A5086946550 @default.
• W2312252295 creator A5087453174 @default.
• W2312252295 date "2015-04-01" @default.
• W2312252295 modified "2023-10-17" @default.
• W2312252295 title "Matrix Metalloproteinases 2 and 9 Polymorphism in Patients With Myeloproliferative Diseases" @default.
• W2312252295 cites W109911703 @default.
• W2312252295 cites W1560533935 @default.
• W2312252295 cites W1593295279 @default.
• W2312252295 cites W1595837679 @default.
• W2312252295 cites W1604907834 @default.
• W2312252295 cites W1768310682 @default.
• W2312252295 cites W1806896498 @default.
• W2312252295 cites W1977066660 @default.
• W2312252295 cites W1979390430 @default.
• W2312252295 cites W1984014167 @default.
• W2312252295 cites W1985235691 @default.
• W2312252295 cites W1993897867 @default.
• W2312252295 cites W2010131482 @default.
• W2312252295 cites W2013215928 @default.
• W2312252295 cites W2014043577 @default.
• W2312252295 cites W2022524633 @default.
• W2312252295 cites W2022955379 @default.
• W2312252295 cites W2025571426 @default.
• W2312252295 cites W2026151657 @default.
• W2312252295 cites W2041913251 @default.
• W2312252295 cites W2045882503 @default.
• W2312252295 cites W2064158585 @default.
• W2312252295 cites W2067886497 @default.
• W2312252295 cites W2071697902 @default.
• W2312252295 cites W2072103796 @default.
• W2312252295 cites W2072460517 @default.
• W2312252295 cites W2075542566 @default.
• W2312252295 cites W2078344536 @default.
• W2312252295 cites W2089334904 @default.
• W2312252295 cites W2098132809 @default.
• W2312252295 cites W2101490863 @default.
• W2312252295 cites W2109365013 @default.
• W2312252295 cites W2115426314 @default.
• W2312252295 cites W2142652390 @default.
• W2312252295 cites W2144576915 @default.
• W2312252295 cites W2145283243 @default.
• W2312252295 cites W2153297806 @default.
• W2312252295 cites W2157367721 @default.
• W2312252295 cites W2157425429 @default.
• W2312252295 cites W2163644607 @default.
• W2312252295 cites W2164287441 @default.
• W2312252295 cites W2168305957 @default.
• W2312252295 cites W2171599453 @default.
• W2312252295 cites W2435525420 @default.
• W2312252295 cites W4238241731 @default.
• W2312252295 cites W4242211382 @default.
• W2312252295 doi "https://doi.org/10.1097/md.0000000000000732" @default.
• W2312252295 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4602695" @default.
• W2312252295 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25906101" @default.
• W2312252295 hasPublicationYear "2015" @default.
• W2312252295 type Work @default.
• W2312252295 sameAs 2312252295 @default.
• W2312252295 citedByCount "16" @default.
• W2312252295 countsByYear W23122522952017 @default.
• W2312252295 countsByYear W23122522952020 @default.
• W2312252295 countsByYear W23122522952021 @default.
• W2312252295 countsByYear W23122522952022 @default.
• W2312252295 countsByYear W23122522952023 @default.
• W2312252295 crossrefType "journal-article" @default.
• W2312252295 hasAuthorship W2312252295A5004097738 @default.
• W2312252295 hasAuthorship W2312252295A5013902236 @default.
• W2312252295 hasAuthorship W2312252295A5014590544 @default.
• W2312252295 hasAuthorship W2312252295A5038885635 @default.
• W2312252295 hasAuthorship W2312252295A5051162121 @default.
• W2312252295 hasAuthorship W2312252295A5057279608 @default.
• W2312252295 hasAuthorship W2312252295A5075525060 @default.
• W2312252295 hasAuthorship W2312252295A5075937522 @default.
• W2312252295 hasAuthorship W2312252295A5086946550 @default.
• W2312252295 hasAuthorship W2312252295A5087453174 @default.
• W2312252295 hasBestOaLocation W23122522951 @default.
• W2312252295 hasConcept C104317684 @default.
• W2312252295 hasConcept C109159458 @default.
• W2312252295 hasConcept C109523444 @default.
• W2312252295 hasConcept C121608353 @default.
• W2312252295 hasConcept C126322002 @default.
• W2312252295 hasConcept C135763542 @default.
• W2312252295 hasConcept C168007829 @default.
• W2312252295 hasConcept C203014093 @default.
• W2312252295 hasConcept C2778837598 @default.
• W2312252295 hasConcept C2779013556 @default.
• W2312252295 hasConcept C2780007613 @default.
• W2312252295 hasConcept C2780076729 @default.
• W2312252295 hasConcept C2780699576 @default.

• next