FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2312323596> ?p ?o ?g. }

• W2312323596 endingPage "1326" @default.
• W2312323596 startingPage "1314" @default.
• W2312323596 abstract "Intrinsically disordered proteins (IDPs) are broadly defined as protein regions that do not cooperatively fold into a spatially or temporally stable structure. Recent research strongly supports the hypothesis that a conserved functional role for structural disorder renders IDPs uniquely capable of functioning in biological processes such as cellular signaling and transcription. Recently, the frequency of application of rigorous mechanistic biochemistry and quantitative biophysics to disordered systems has increased dramatically. For example, the launch of the Protein Ensemble Database (pE-DB) demonstrates that the potential now exists to refine models for the native state structure of IDPs using experimental data. However, rigorous assessment of which observables place the strongest and least biased constraints on those ensembles is now needed. Most importantly, the past few years have seen strong growth in the number of biochemical and biophysical studies attempting to connect structural disorder with function. From the perspective of equilibrium thermodynamics, there is a clear need to assess the relative significance of hydrophobic versus electrostatic forces in IDP interactions, if it is possible to generalize at all. Finally, kinetic mechanisms that invoke conformational selection and/or induced fit are often used to characterize coupled IDP folding and binding, although application of these models is typically built upon thermodynamic observations. Recently, the reaction rates and kinetic mechanisms of more intrinsically disordered systems have been tested through rigorous kinetic experiments. Motivated by these exciting advances, here we provide a review and prospectus for the quantitative study of IDP structure, thermodynamics, and kinetics." @default.
• W2312323596 created "2016-06-24" @default.
• W2312323596 creator A5024933190 @default.
• W2312323596 creator A5047930774 @default.
• W2312323596 date "2015-02-06" @default.
• W2312323596 modified "2023-09-26" @default.
• W2312323596 title "Quantitative Biophysical Characterization of Intrinsically Disordered Proteins" @default.
• W2312323596 cites W1482811565 @default.
• W2312323596 cites W1501347866 @default.
• W2312323596 cites W155626891 @default.
• W2312323596 cites W1578748697 @default.
• W2312323596 cites W1935970151 @default.
• W2312323596 cites W1964983953 @default.
• W2312323596 cites W1968402031 @default.
• W2312323596 cites W1970022221 @default.
• W2312323596 cites W1970094326 @default.
• W2312323596 cites W1971803615 @default.
• W2312323596 cites W1973699439 @default.
• W2312323596 cites W1974111953 @default.
• W2312323596 cites W1974523101 @default.
• W2312323596 cites W1976116660 @default.
• W2312323596 cites W1980015132 @default.
• W2312323596 cites W1980784169 @default.
• W2312323596 cites W1984191940 @default.
• W2312323596 cites W1986580794 @default.
• W2312323596 cites W1993422461 @default.
• W2312323596 cites W1993549705 @default.
• W2312323596 cites W1994454005 @default.
• W2312323596 cites W1994840640 @default.
• W2312323596 cites W1995586409 @default.
• W2312323596 cites W2001539906 @default.
• W2312323596 cites W2002900623 @default.
• W2312323596 cites W2007829343 @default.
• W2312323596 cites W2007905703 @default.
• W2312323596 cites W2008765876 @default.
• W2312323596 cites W2009084328 @default.
• W2312323596 cites W2010236707 @default.
• W2312323596 cites W2011983814 @default.
• W2312323596 cites W2013491063 @default.
• W2312323596 cites W2013593586 @default.
• W2312323596 cites W2014764365 @default.
• W2312323596 cites W2014904337 @default.
• W2312323596 cites W2015392215 @default.
• W2312323596 cites W2015414493 @default.
• W2312323596 cites W2015542247 @default.
• W2312323596 cites W2016094489 @default.
• W2312323596 cites W2022201177 @default.
• W2312323596 cites W2023487073 @default.
• W2312323596 cites W2028059774 @default.
• W2312323596 cites W2031928292 @default.
• W2312323596 cites W2033782813 @default.
• W2312323596 cites W2033995262 @default.
• W2312323596 cites W2034016778 @default.
• W2312323596 cites W2034602828 @default.
• W2312323596 cites W2034693855 @default.
• W2312323596 cites W2038227807 @default.
• W2312323596 cites W2038895598 @default.
• W2312323596 cites W2038916674 @default.
• W2312323596 cites W2039297817 @default.
• W2312323596 cites W2040355223 @default.
• W2312323596 cites W2040762668 @default.
• W2312323596 cites W2040934203 @default.
• W2312323596 cites W2041000185 @default.
• W2312323596 cites W2044730187 @default.
• W2312323596 cites W2047408214 @default.
• W2312323596 cites W2049073062 @default.
• W2312323596 cites W2052204832 @default.
• W2312323596 cites W2058238447 @default.
• W2312323596 cites W2058532979 @default.
• W2312323596 cites W2059324308 @default.
• W2312323596 cites W2060884632 @default.
• W2312323596 cites W2061270176 @default.
• W2312323596 cites W2063237839 @default.
• W2312323596 cites W2066962978 @default.
• W2312323596 cites W2067190679 @default.
• W2312323596 cites W2068751599 @default.
• W2312323596 cites W2069689165 @default.
• W2312323596 cites W2071739990 @default.
• W2312323596 cites W2072259830 @default.
• W2312323596 cites W2072470481 @default.
• W2312323596 cites W2072675685 @default.
• W2312323596 cites W2074661080 @default.
• W2312323596 cites W2076296582 @default.
• W2312323596 cites W2078034776 @default.
• W2312323596 cites W2078525643 @default.
• W2312323596 cites W2080656302 @default.
• W2312323596 cites W2084611577 @default.
• W2312323596 cites W2086189298 @default.
• W2312323596 cites W2087437523 @default.
• W2312323596 cites W2089839753 @default.
• W2312323596 cites W2090216113 @default.
• W2312323596 cites W2091472818 @default.
• W2312323596 cites W2091625914 @default.
• W2312323596 cites W2091780015 @default.
• W2312323596 cites W2093177467 @default.
• W2312323596 cites W2093605276 @default.
• W2312323596 cites W2096929343 @default.
• W2312323596 cites W2097891553 @default.

• next