Matches in SemOpenAlex for { <https://semopenalex.org/work/W2312325831> ?p ?o ?g. }
- W2312325831 abstract "Significance Improved regimens for treatment of tuberculosis are needed to shorten the duration of treatment and combat the emergence of drug resistance. Selection of optimized regimens requires assessment of numerous combinations of existing drugs at multiple dose levels. This requirement presents a challenge because of the exponentially large number of combinations— N M for N doses of M drugs. We show here using a high-throughput macrophage model of Mycobacterium tuberculosis infection that a feedback system control technique can determine optimal drug treatment regimens by testing a relatively small number of drug–dose combinations. In an independent assay measuring intramacrophage killing of M. tuberculosis , the optimized regimens are superior to the current standard regimen." @default.
- W2312325831 created "2016-06-24" @default.
- W2312325831 creator A5009767255 @default.
- W2312325831 creator A5045756899 @default.
- W2312325831 creator A5062026780 @default.
- W2312325831 creator A5073717131 @default.
- W2312325831 creator A5075601170 @default.
- W2312325831 creator A5085024060 @default.
- W2312325831 creator A5087108704 @default.
- W2312325831 date "2016-03-28" @default.
- W2312325831 modified "2023-10-12" @default.
- W2312325831 title "Output-driven feedback system control platform optimizes combinatorial therapy of tuberculosis using a macrophage cell culture model" @default.
- W2312325831 cites W1512579301 @default.
- W2312325831 cites W1979303572 @default.
- W2312325831 cites W2000905457 @default.
- W2312325831 cites W2008515696 @default.
- W2312325831 cites W2031907936 @default.
- W2312325831 cites W2032448480 @default.
- W2312325831 cites W2071711748 @default.
- W2312325831 cites W2130960804 @default.
- W2312325831 cites W2135193803 @default.
- W2312325831 cites W2148912284 @default.
- W2312325831 cites W2150776537 @default.
- W2312325831 cites W2154585313 @default.
- W2312325831 cites W2156761481 @default.
- W2312325831 cites W2158011874 @default.
- W2312325831 cites W2158409385 @default.
- W2312325831 cites W2178981763 @default.
- W2312325831 cites W2194348484 @default.
- W2312325831 doi "https://doi.org/10.1073/pnas.1600812113" @default.
- W2312325831 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4839402" @default.
- W2312325831 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27035987" @default.
- W2312325831 hasPublicationYear "2016" @default.
- W2312325831 type Work @default.
- W2312325831 sameAs 2312325831 @default.
- W2312325831 citedByCount "70" @default.
- W2312325831 countsByYear W23123258312016 @default.
- W2312325831 countsByYear W23123258312017 @default.
- W2312325831 countsByYear W23123258312018 @default.
- W2312325831 countsByYear W23123258312019 @default.
- W2312325831 countsByYear W23123258312020 @default.
- W2312325831 countsByYear W23123258312021 @default.
- W2312325831 countsByYear W23123258312022 @default.
- W2312325831 countsByYear W23123258312023 @default.
- W2312325831 crossrefType "journal-article" @default.
- W2312325831 hasAuthorship W2312325831A5009767255 @default.
- W2312325831 hasAuthorship W2312325831A5045756899 @default.
- W2312325831 hasAuthorship W2312325831A5062026780 @default.
- W2312325831 hasAuthorship W2312325831A5073717131 @default.
- W2312325831 hasAuthorship W2312325831A5075601170 @default.
- W2312325831 hasAuthorship W2312325831A5085024060 @default.
- W2312325831 hasAuthorship W2312325831A5087108704 @default.
- W2312325831 hasBestOaLocation W23123258311 @default.
- W2312325831 hasConcept C114851261 @default.
- W2312325831 hasConcept C126322002 @default.
- W2312325831 hasConcept C142724271 @default.
- W2312325831 hasConcept C202751555 @default.
- W2312325831 hasConcept C203014093 @default.
- W2312325831 hasConcept C2777975735 @default.
- W2312325831 hasConcept C2779244956 @default.
- W2312325831 hasConcept C2780035454 @default.
- W2312325831 hasConcept C2781069245 @default.
- W2312325831 hasConcept C2781413609 @default.
- W2312325831 hasConcept C3020294253 @default.
- W2312325831 hasConcept C55493867 @default.
- W2312325831 hasConcept C71924100 @default.
- W2312325831 hasConcept C86803240 @default.
- W2312325831 hasConcept C89423630 @default.
- W2312325831 hasConcept C98274493 @default.
- W2312325831 hasConceptScore W2312325831C114851261 @default.
- W2312325831 hasConceptScore W2312325831C126322002 @default.
- W2312325831 hasConceptScore W2312325831C142724271 @default.
- W2312325831 hasConceptScore W2312325831C202751555 @default.
- W2312325831 hasConceptScore W2312325831C203014093 @default.
- W2312325831 hasConceptScore W2312325831C2777975735 @default.
- W2312325831 hasConceptScore W2312325831C2779244956 @default.
- W2312325831 hasConceptScore W2312325831C2780035454 @default.
- W2312325831 hasConceptScore W2312325831C2781069245 @default.
- W2312325831 hasConceptScore W2312325831C2781413609 @default.
- W2312325831 hasConceptScore W2312325831C3020294253 @default.
- W2312325831 hasConceptScore W2312325831C55493867 @default.
- W2312325831 hasConceptScore W2312325831C71924100 @default.
- W2312325831 hasConceptScore W2312325831C86803240 @default.
- W2312325831 hasConceptScore W2312325831C89423630 @default.
- W2312325831 hasConceptScore W2312325831C98274493 @default.
- W2312325831 hasFunder F4320306137 @default.
- W2312325831 hasFunder F4320322999 @default.
- W2312325831 hasIssue "15" @default.
- W2312325831 hasLocation W23123258311 @default.
- W2312325831 hasLocation W23123258312 @default.
- W2312325831 hasLocation W23123258313 @default.
- W2312325831 hasLocation W23123258314 @default.
- W2312325831 hasOpenAccess W2312325831 @default.
- W2312325831 hasPrimaryLocation W23123258311 @default.
- W2312325831 hasRelatedWork W1829694811 @default.
- W2312325831 hasRelatedWork W2069945100 @default.
- W2312325831 hasRelatedWork W2310768725 @default.
- W2312325831 hasRelatedWork W2355728116 @default.
- W2312325831 hasRelatedWork W2361803958 @default.
- W2312325831 hasRelatedWork W2391692338 @default.