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• W2312359123 abstract "To determine risk factors for high lung shunt fraction (LSF) (LSF>20%) measured by technetium-99m macroaggregated albumin (99mTc-MAA) scan in patients with hepatocellular carcinoma (HCC) Our cohort consists of 428 subjects with HCC from 2004 to 2011 who were assessed for hepatopulmonary shunting by MAA. LSF measurements were obtained for each patient and categorized into low (LSF<10%), intermediate (LSF 10%-20%), and high (LSF>20%). Patient characteristics were investigated for correlation/association with high LSF and included age, gender, ethnicity, tumor burden (%), maximum dimension, focality, presence of extrahepatic metastases, portal venous thrombosis, ascites on imaging, baseline laboratory values, change in alpha-fetoprotein, and multiple staging systems. The positive likelihood ratios (LR+) and Pearson correlation coefficients (“r”) of LSF>20% versus LSF≤20% were determined. Positive predictive values (PPV) for LSF>20% were also calculated. K-M and log-rank testing were used for analysis. Factors showing statistically significant (p<0.05) association with high LSF included serum AFP, albumin, and alkaline phosphatase; ascites on abdominal imaging; tumor infiltration; tumor burden; lobar distribution; focality; tumor size; portal venous thrombosis; extrahepatic disease; performance status; and several tumor staging systems. Most characteristics yielded low LR+ and PPV, as well as “r” coefficients close to 0. Notable findings included PPV of 0.32 for alkaline phosphatase > 200 U/L, PPV of 0.25 for tumor diameter > 10 cm, and 0.24 and 0.35 for Cancer of the Liver Italian Program (CLIP) stages 4 and 5, respectively. Several characteristics are statistically significant but weakly predictive of high LSF; these include laboratory values, imaging findings, and clinical assessments. However, these factors cannot serve as an adequate substitute for LSF determined by 99mTc-MAA in clinical practice." @default.
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• W2312359123 date "2016-03-01" @default.
• W2312359123 modified "2023-09-24" @default.
• W2312359123 title "Risk factors for high lung shunt fraction in patients with hepatocellular carcinoma being evaluated for yttrium-90 radioembolization" @default.
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• W2312359123 doi "https://doi.org/10.1016/j.jvir.2015.12.180" @default.
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