Matches in SemOpenAlex for { <https://semopenalex.org/work/W2312418312> ?p ?o ?g. }
- W2312418312 endingPage "624" @default.
- W2312418312 startingPage "617" @default.
- W2312418312 abstract "The aim of the present study was to develop and optimize topically applied nimesulide-loaded nanostructured lipid carriers.Box-Behnken experimental design was applied for optimization of nanostructured lipid carriers. The independent variables were ratio of stearic acid: oleic acid (X1), poloxamer 188 concentration (X2) and lecithin concentration (X3) while particle size (Y1) and entrapment efficiency (Y2) were the chosen responses. Further, skin penetration study, in vitro release, confocal laser scanning microscopy and stability study were also performed.The optimized nanostructured lipid carriers of nimesulide provide reasonable particle size, flux, and entrapment efficiency. Optimized formulation (F9) with mean particle size of 214.4 ± 11 nm showed 89.4 ± 3.40% entrapment efficiency and achieved mean flux 2.66 ± 0.09 μg/cm2/h. In vitro release study showed prolonged drug release from the optimized formulation following Higuchi release kinetics with R2 value of 0.984. Confocal laser scanning microscopy revealed an enhanced penetration of Rhodamine B-loaded nanostructured lipid carriers to the deeper layers of the skin. The stability study confirmed that the optimized formulation was considerably stable at refrigerator temperature as compared to room temperature.Our results concluded that nanostructured lipid carriers are an efficient carrier for topical delivery of nimesulide." @default.
- W2312418312 created "2016-06-24" @default.
- W2312418312 creator A5003677451 @default.
- W2312418312 creator A5017365328 @default.
- W2312418312 creator A5064337706 @default.
- W2312418312 creator A5069899863 @default.
- W2312418312 creator A5089261501 @default.
- W2312418312 date "2016-04-06" @default.
- W2312418312 modified "2023-10-16" @default.
- W2312418312 title "Optimization of nanostructured lipid carriers for topical delivery of nimesulide using Box–Behnken design approach" @default.
- W2312418312 cites W1972404415 @default.
- W2312418312 cites W1974166640 @default.
- W2312418312 cites W1976994180 @default.
- W2312418312 cites W1977072597 @default.
- W2312418312 cites W1978647910 @default.
- W2312418312 cites W1978969564 @default.
- W2312418312 cites W1983727696 @default.
- W2312418312 cites W2003952694 @default.
- W2312418312 cites W2015269487 @default.
- W2312418312 cites W2022084212 @default.
- W2312418312 cites W2027788495 @default.
- W2312418312 cites W2028338264 @default.
- W2312418312 cites W2042446530 @default.
- W2312418312 cites W2047372391 @default.
- W2312418312 cites W2049219074 @default.
- W2312418312 cites W2049626483 @default.
- W2312418312 cites W2051959623 @default.
- W2312418312 cites W2071322745 @default.
- W2312418312 cites W2079357053 @default.
- W2312418312 cites W2085692671 @default.
- W2312418312 cites W2086130473 @default.
- W2312418312 cites W2089229095 @default.
- W2312418312 cites W2090202564 @default.
- W2312418312 cites W2105153063 @default.
- W2312418312 cites W2115235394 @default.
- W2312418312 cites W2120342328 @default.
- W2312418312 cites W2136335396 @default.
- W2312418312 cites W2137017984 @default.
- W2312418312 cites W2147511063 @default.
- W2312418312 cites W2159996436 @default.
- W2312418312 cites W2168649017 @default.
- W2312418312 cites W2169336676 @default.
- W2312418312 cites W2315133821 @default.
- W2312418312 cites W4231481460 @default.
- W2312418312 doi "https://doi.org/10.3109/21691401.2016.1167699" @default.
- W2312418312 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27050533" @default.
- W2312418312 hasPublicationYear "2016" @default.
- W2312418312 type Work @default.
- W2312418312 sameAs 2312418312 @default.
- W2312418312 citedByCount "55" @default.
- W2312418312 countsByYear W23124183122016 @default.
- W2312418312 countsByYear W23124183122017 @default.
- W2312418312 countsByYear W23124183122018 @default.
- W2312418312 countsByYear W23124183122019 @default.
- W2312418312 countsByYear W23124183122020 @default.
- W2312418312 countsByYear W23124183122021 @default.
- W2312418312 countsByYear W23124183122022 @default.
- W2312418312 countsByYear W23124183122023 @default.
- W2312418312 crossrefType "journal-article" @default.
- W2312418312 hasAuthorship W2312418312A5003677451 @default.
- W2312418312 hasAuthorship W2312418312A5017365328 @default.
- W2312418312 hasAuthorship W2312418312A5064337706 @default.
- W2312418312 hasAuthorship W2312418312A5069899863 @default.
- W2312418312 hasAuthorship W2312418312A5089261501 @default.
- W2312418312 hasBestOaLocation W23124183121 @default.
- W2312418312 hasConcept C101335993 @default.
- W2312418312 hasConcept C127413603 @default.
- W2312418312 hasConcept C13245373 @default.
- W2312418312 hasConcept C150077022 @default.
- W2312418312 hasConcept C155672457 @default.
- W2312418312 hasConcept C15920480 @default.
- W2312418312 hasConcept C159985019 @default.
- W2312418312 hasConcept C170295934 @default.
- W2312418312 hasConcept C171250308 @default.
- W2312418312 hasConcept C18150654 @default.
- W2312418312 hasConcept C185592680 @default.
- W2312418312 hasConcept C187530423 @default.
- W2312418312 hasConcept C192562407 @default.
- W2312418312 hasConcept C2777570176 @default.
- W2312418312 hasConcept C2779820397 @default.
- W2312418312 hasConcept C42360764 @default.
- W2312418312 hasConcept C42475967 @default.
- W2312418312 hasConcept C43617362 @default.
- W2312418312 hasConcept C521977710 @default.
- W2312418312 hasConcept C55493867 @default.
- W2312418312 hasConcept C80107235 @default.
- W2312418312 hasConceptScore W2312418312C101335993 @default.
- W2312418312 hasConceptScore W2312418312C127413603 @default.
- W2312418312 hasConceptScore W2312418312C13245373 @default.
- W2312418312 hasConceptScore W2312418312C150077022 @default.
- W2312418312 hasConceptScore W2312418312C155672457 @default.
- W2312418312 hasConceptScore W2312418312C15920480 @default.
- W2312418312 hasConceptScore W2312418312C159985019 @default.
- W2312418312 hasConceptScore W2312418312C170295934 @default.
- W2312418312 hasConceptScore W2312418312C171250308 @default.
- W2312418312 hasConceptScore W2312418312C18150654 @default.
- W2312418312 hasConceptScore W2312418312C185592680 @default.
- W2312418312 hasConceptScore W2312418312C187530423 @default.