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• W2312528980 abstract "Background: Since the advent of highly active antiretroviral therapy, patients with human immunodeficiency virus (HIV) infection lead longer survival and death from non-AIDS-defining cancers (NADCs) is recently much more common. Japan has an increasing number of newly diagnosed colorectal cancer (CRC) and HIV-infected patients respectively, however, lack consensus on management and therapeutic approaches to HIV-infected CRC patients.Patients and methods: We retrospectively analyzed 8 Japanese patients diagnosed with both HIV-infection and CRC, excluding anal cancer, in our hospital between 1986 and 2012.Result: All 8 patients were men, with a mean age of 61.1 (53-74) at the time of CRC diagnosis. Mean CD4 cell count was 291.5 cells/µL (211-424), and HIV viral load was undetectable in 6 patients on CRC diagnosis. 2 patients were diagnosed simultaneously, while 6 patients were diagnosed CRC after diagnosis of HIV-infection. Lesions of tumor was colon in 6, and rectum in 2 patients, both of which were negative for human papilloma virus. Histological subtype was adenocarcinoma in 7 patients, and squamous cell carcinoma in 1 patient. 2/4/1/1 patients demonstrated stages I/II/III/IV, respectively, and 7 underwent curative-intended surgery. 3 patients underwent chemotherapy due to metastasis or recurrence. Median overall survival was not reached (95% confidential interval: 6.01-not reached) for all patients, and for the 3 patients undergoing chemotherapy, the survival time was 18, 26, and 53 months, respectively.Conclusion: HIV-infected CRC patients can be treated with the similar multimodal approach as the non-HIV infected population and also anticipated a good prognosis, with close collaboration among medical oncologists, surgical oncologists, and infectious disease physicians. Background: Since the advent of highly active antiretroviral therapy, patients with human immunodeficiency virus (HIV) infection lead longer survival and death from non-AIDS-defining cancers (NADCs) is recently much more common. Japan has an increasing number of newly diagnosed colorectal cancer (CRC) and HIV-infected patients respectively, however, lack consensus on management and therapeutic approaches to HIV-infected CRC patients. Patients and methods: We retrospectively analyzed 8 Japanese patients diagnosed with both HIV-infection and CRC, excluding anal cancer, in our hospital between 1986 and 2012. Result: All 8 patients were men, with a mean age of 61.1 (53-74) at the time of CRC diagnosis. Mean CD4 cell count was 291.5 cells/µL (211-424), and HIV viral load was undetectable in 6 patients on CRC diagnosis. 2 patients were diagnosed simultaneously, while 6 patients were diagnosed CRC after diagnosis of HIV-infection. Lesions of tumor was colon in 6, and rectum in 2 patients, both of which were negative for human papilloma virus. Histological subtype was adenocarcinoma in 7 patients, and squamous cell carcinoma in 1 patient. 2/4/1/1 patients demonstrated stages I/II/III/IV, respectively, and 7 underwent curative-intended surgery. 3 patients underwent chemotherapy due to metastasis or recurrence. Median overall survival was not reached (95% confidential interval: 6.01-not reached) for all patients, and for the 3 patients undergoing chemotherapy, the survival time was 18, 26, and 53 months, respectively. Conclusion: HIV-infected CRC patients can be treated with the similar multimodal approach as the non-HIV infected population and also anticipated a good prognosis, with close collaboration among medical oncologists, surgical oncologists, and infectious disease physicians." @default.
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• W2312528980 date "2013-11-01" @default.
• W2312528980 modified "2023-10-16" @default.
• W2312528980 title "Clinical Demographics and Multimodal Therapy for Colorectal Cancer Patients with Human Immunodeficiency Virus Infection" @default.
• W2312528980 doi "https://doi.org/10.1093/annonc/mdt459.109" @default.
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