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- W2312530145 abstract "Approximately 10-20% of all sudden cardiac deaths are caused by entities that are not associated with structural heart disease. The congenital channelopathies or primary electrical diseases are the most frequent cause of sudden cardiac death in the presence of a structurally normal heart.. The most frequent congenital channelopathies that manifest with sudden cardiac death are: the long QT syndrome, Brugada syndrome, congenital short QT syndrome and catecholaminergic polymorphic ventricular tachycardia. These congenital cardiac channelopathies may have several overlapping clinical and electrocardiographic phenotypes. The phenotype expression based on ECG manifestations is critical for reaching the appropriate diagnosis. Molecular diagnosis based on identification of gene mutations is challenging and remains an area of rapid development as a significant proportion of patients that have the ECG phenotypic alteration may prove to have no identifiable mutations. The prevalence of these diseases is low and consequently no large prospective randomized studies have been conducted. Thus, risk stratification in these patients based on retrospective data derived from singleor multicenter registries remains the cornerstone for risk assessment in patients with congenital channelopathies. The present article reviews the most frequent congenital channelopathies and provides some recommendations for risk stratification in this challenging group of patients." @default.
- W2312530145 created "2016-06-24" @default.
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- W2312530145 creator A5038943660 @default.
- W2312530145 date "2009-01-01" @default.
- W2312530145 modified "2023-09-25" @default.
- W2312530145 title "Estratificación del riesgo en las canalopatías congenitas" @default.
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- W2312530145 doi "https://doi.org/10.5031/v1i2.ria10119" @default.
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