FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2312531330> ?p ?o ?g. }

• W2312531330 endingPage "1177" @default.
• W2312531330 startingPage "1172" @default.
• W2312531330 abstract "Traditionally, characterization of protein molecules conjugated with molecular probes is performed by UV–vis spectroscopy. This method determines the average incorporation ratio but does not yield information about the label distribution. Electrospray ionization mass spectroscopy (ESI-MS) allows direct measurement of the fraction of protein containing a given number of labels. However, for a glycosylated protein, this analysis can be severely limited due to spectral overlap of the labels and carbohydrates. To address this problem, we introduce the mass spread function (MSF) for conjugation analysis. By treating the ESI-MS spectrum of conjugated protein as the spectrum before conjugation convolved with the MSF, we are able to quantify the labeled protein population using a binomial distribution function. We first applied this procedure for characterization of labeled antibody F(ab′)2 fragments which do not contain carbohydrates. We then apply the MSF to fit spectra of entire conjugated monoclonal antibodies and quantify the distribution of labels in the presence of glycans." @default.
• W2312531330 created "2016-06-24" @default.
• W2312531330 creator A5014154553 @default.
• W2312531330 creator A5023136812 @default.
• W2312531330 creator A5027757071 @default.
• W2312531330 creator A5028014036 @default.
• W2312531330 creator A5036778302 @default.
• W2312531330 creator A5040322375 @default.
• W2312531330 creator A5053400899 @default.
• W2312531330 date "2011-12-22" @default.
• W2312531330 modified "2023-09-23" @default.
• W2312531330 title "Introduction of the Mass Spread Function for Characterization of Protein Conjugates" @default.
• W2312531330 cites W1966625877 @default.
• W2312531330 cites W2031062088 @default.
• W2312531330 cites W2034609970 @default.
• W2312531330 cites W2054048234 @default.
• W2312531330 cites W2068343396 @default.
• W2312531330 cites W2087662363 @default.
• W2312531330 cites W2088005853 @default.
• W2312531330 cites W2117531628 @default.
• W2312531330 cites W2168057633 @default.
• W2312531330 cites W2224139360 @default.
• W2312531330 cites W2234971772 @default.
• W2312531330 cites W4245829070 @default.
• W2312531330 doi "https://doi.org/10.1021/ac202239j" @default.
• W2312531330 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22128896" @default.
• W2312531330 hasPublicationYear "2011" @default.
• W2312531330 type Work @default.
• W2312531330 sameAs 2312531330 @default.
• W2312531330 citedByCount "8" @default.
• W2312531330 countsByYear W23125313302012 @default.
• W2312531330 countsByYear W23125313302014 @default.
• W2312531330 countsByYear W23125313302015 @default.
• W2312531330 countsByYear W23125313302016 @default.
• W2312531330 countsByYear W23125313302020 @default.
• W2312531330 crossrefType "journal-article" @default.
• W2312531330 hasAuthorship W2312531330A5014154553 @default.
• W2312531330 hasAuthorship W2312531330A5023136812 @default.
• W2312531330 hasAuthorship W2312531330A5027757071 @default.
• W2312531330 hasAuthorship W2312531330A5028014036 @default.
• W2312531330 hasAuthorship W2312531330A5036778302 @default.
• W2312531330 hasAuthorship W2312531330A5040322375 @default.
• W2312531330 hasAuthorship W2312531330A5053400899 @default.
• W2312531330 hasConcept C112613896 @default.
• W2312531330 hasConcept C113196181 @default.
• W2312531330 hasConcept C121332964 @default.
• W2312531330 hasConcept C134306372 @default.
• W2312531330 hasConcept C144024400 @default.
• W2312531330 hasConcept C149923435 @default.
• W2312531330 hasConcept C162356407 @default.
• W2312531330 hasConcept C171250308 @default.
• W2312531330 hasConcept C178790620 @default.
• W2312531330 hasConcept C181199279 @default.
• W2312531330 hasConcept C185592680 @default.
• W2312531330 hasConcept C186060115 @default.
• W2312531330 hasConcept C192562407 @default.
• W2312531330 hasConcept C194451485 @default.
• W2312531330 hasConcept C197336794 @default.
• W2312531330 hasConcept C2780841128 @default.
• W2312531330 hasConcept C2908647359 @default.
• W2312531330 hasConcept C32891209 @default.
• W2312531330 hasConcept C33923547 @default.
• W2312531330 hasConcept C40684141 @default.
• W2312531330 hasConcept C43617362 @default.
• W2312531330 hasConcept C521977710 @default.
• W2312531330 hasConcept C55493867 @default.
• W2312531330 hasConcept C58121356 @default.
• W2312531330 hasConcept C62520636 @default.
• W2312531330 hasConcept C86803240 @default.
• W2312531330 hasConceptScore W2312531330C112613896 @default.
• W2312531330 hasConceptScore W2312531330C113196181 @default.
• W2312531330 hasConceptScore W2312531330C121332964 @default.
• W2312531330 hasConceptScore W2312531330C134306372 @default.
• W2312531330 hasConceptScore W2312531330C144024400 @default.
• W2312531330 hasConceptScore W2312531330C149923435 @default.
• W2312531330 hasConceptScore W2312531330C162356407 @default.
• W2312531330 hasConceptScore W2312531330C171250308 @default.
• W2312531330 hasConceptScore W2312531330C178790620 @default.
• W2312531330 hasConceptScore W2312531330C181199279 @default.
• W2312531330 hasConceptScore W2312531330C185592680 @default.
• W2312531330 hasConceptScore W2312531330C186060115 @default.
• W2312531330 hasConceptScore W2312531330C192562407 @default.
• W2312531330 hasConceptScore W2312531330C194451485 @default.
• W2312531330 hasConceptScore W2312531330C197336794 @default.
• W2312531330 hasConceptScore W2312531330C2780841128 @default.
• W2312531330 hasConceptScore W2312531330C2908647359 @default.
• W2312531330 hasConceptScore W2312531330C32891209 @default.
• W2312531330 hasConceptScore W2312531330C33923547 @default.
• W2312531330 hasConceptScore W2312531330C40684141 @default.
• W2312531330 hasConceptScore W2312531330C43617362 @default.
• W2312531330 hasConceptScore W2312531330C521977710 @default.
• W2312531330 hasConceptScore W2312531330C55493867 @default.
• W2312531330 hasConceptScore W2312531330C58121356 @default.
• W2312531330 hasConceptScore W2312531330C62520636 @default.
• W2312531330 hasConceptScore W2312531330C86803240 @default.
• W2312531330 hasIssue "2" @default.
• W2312531330 hasLocation W23125313301 @default.
• W2312531330 hasLocation W23125313302 @default.

• next