FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2312562842> ?p ?o ?g. }

• W2312562842 endingPage "367" @default.
• W2312562842 startingPage "359" @default.
• W2312562842 abstract "The detection and elimination of minimal systemic disease in patients with solid tumors is one of the main current topics in clinical oncology. The present review focuses, therefore, on new diagnostic approaches to identify minimal disease in peripheral blood, bone marrow, and lymph nodes of patients with epithelial cancer as the major type of solid tumors in Western industrialized countries. These approaches may be used to improve tumor staging and monitoring of adjuvant therapies, as well as to detect tumor cell contamination in autologous stem cell grafts. Most investigators have developed either immunocytochemical assays with monoclonal antibodies to a variety of epithelial-specific cytoskeleton and membrane antigens or molecular methods based on the extensive amplification of a specific (c)DNA sequence by the polymerase-chain reaction (PCR). In immunocytochemical assays, antibodies to cytokeratins can be regarded as the most specific and sensitive probes to detect isolated epithelial tumor cells in bone marrow and blood. Molecular methods are based on the detection of either mutations in oncogenes and tumor suppressor genes (e.g., ki-ras and p53 genes) or the mRNA expression of tissue-specific and tumor-associated genes. mRNA species targeted in these assays encode cytokeratins, prostate-specific antigen, prostate-specific membrane antigen, carcinoembryonic antigen, and polymorphic-epithelial mucin. To introduce the available methods into clinical practice, standardized protocols need to be developed and validated in multicenter studies." @default.
• W2312562842 created "2016-06-24" @default.
• W2312562842 creator A5048105827 @default.
• W2312562842 date "1996-08-01" @default.
• W2312562842 modified "2023-09-27" @default.
• W2312562842 title "Detection of Minimal Disease in Patients with Solid Tumors" @default.
• W2312562842 cites W161630099 @default.
• W2312562842 cites W1718110320 @default.
• W2312562842 cites W1748734394 @default.
• W2312562842 cites W1814183605 @default.
• W2312562842 cites W1823334611 @default.
• W2312562842 cites W1852147417 @default.
• W2312562842 cites W1864823043 @default.
• W2312562842 cites W1900548292 @default.
• W2312562842 cites W1929693340 @default.
• W2312562842 cites W1933088330 @default.
• W2312562842 cites W1953419682 @default.
• W2312562842 cites W1966371639 @default.
• W2312562842 cites W1970137322 @default.
• W2312562842 cites W1974482805 @default.
• W2312562842 cites W1979595385 @default.
• W2312562842 cites W1983670701 @default.
• W2312562842 cites W1987509621 @default.
• W2312562842 cites W1998881872 @default.
• W2312562842 cites W2004214170 @default.
• W2312562842 cites W2004716845 @default.
• W2312562842 cites W2011820948 @default.
• W2312562842 cites W2016024084 @default.
• W2312562842 cites W2018520048 @default.
• W2312562842 cites W2019931839 @default.
• W2312562842 cites W2040129015 @default.
• W2312562842 cites W2041087746 @default.
• W2312562842 cites W2041524945 @default.
• W2312562842 cites W2043041181 @default.
• W2312562842 cites W2055210271 @default.
• W2312562842 cites W2056507674 @default.
• W2312562842 cites W2056777828 @default.
• W2312562842 cites W2059488855 @default.
• W2312562842 cites W2060083625 @default.
• W2312562842 cites W2065006933 @default.
• W2312562842 cites W2067681714 @default.
• W2312562842 cites W2071034864 @default.
• W2312562842 cites W2077699851 @default.
• W2312562842 cites W2080233751 @default.
• W2312562842 cites W2081095585 @default.
• W2312562842 cites W2086264696 @default.
• W2312562842 cites W2105471967 @default.
• W2312562842 cites W2115615594 @default.
• W2312562842 cites W2134045449 @default.
• W2312562842 cites W2155446082 @default.
• W2312562842 cites W2159966721 @default.
• W2312562842 cites W2162992800 @default.
• W2312562842 cites W2218220018 @default.
• W2312562842 cites W2242711566 @default.
• W2312562842 cites W2243522452 @default.
• W2312562842 cites W2267405788 @default.
• W2312562842 cites W2324339443 @default.
• W2312562842 cites W2341209396 @default.
• W2312562842 cites W2414576374 @default.
• W2312562842 cites W2436610849 @default.
• W2312562842 cites W2466637424 @default.
• W2312562842 cites W3112391997 @default.
• W2312562842 cites W4235958234 @default.
• W2312562842 cites W4243990921 @default.
• W2312562842 cites W4249473536 @default.
• W2312562842 cites W4361868702 @default.
• W2312562842 cites W4372214343 @default.
• W2312562842 cites W72650883 @default.
• W2312562842 doi "https://doi.org/10.1089/scd.1.1996.5.359" @default.
• W2312562842 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8877711" @default.
• W2312562842 hasPublicationYear "1996" @default.
• W2312562842 type Work @default.
• W2312562842 sameAs 2312562842 @default.
• W2312562842 citedByCount "46" @default.
• W2312562842 countsByYear W23125628422012 @default.
• W2312562842 countsByYear W23125628422016 @default.
• W2312562842 crossrefType "journal-article" @default.
• W2312562842 hasAuthorship W2312562842A5048105827 @default.
• W2312562842 hasConcept C121608353 @default.
• W2312562842 hasConcept C142724271 @default.
• W2312562842 hasConcept C147483822 @default.
• W2312562842 hasConcept C153911025 @default.
• W2312562842 hasConcept C203014093 @default.
• W2312562842 hasConcept C2777387746 @default.
• W2312562842 hasConcept C2779823535 @default.
• W2312562842 hasConcept C2780007613 @default.
• W2312562842 hasConcept C2781053203 @default.
• W2312562842 hasConcept C502942594 @default.
• W2312562842 hasConcept C54355233 @default.
• W2312562842 hasConcept C71924100 @default.
• W2312562842 hasConcept C86803240 @default.
• W2312562842 hasConceptScore W2312562842C121608353 @default.
• W2312562842 hasConceptScore W2312562842C142724271 @default.
• W2312562842 hasConceptScore W2312562842C147483822 @default.
• W2312562842 hasConceptScore W2312562842C153911025 @default.
• W2312562842 hasConceptScore W2312562842C203014093 @default.
• W2312562842 hasConceptScore W2312562842C2777387746 @default.
• W2312562842 hasConceptScore W2312562842C2779823535 @default.

• next