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- W2312565798 abstract "A library of 484 imidazole-based candidate inhibitors was tested against 24 protein kinases. The resulting activity data have been systematically analyzed to search for compounds that effectively differentiate between kinases. Six imidazole derivatives with high kinase differentiation potential were identified. Nearest neighbor analysis revealed the presence of close analogues with varying differentiation potential. Small structural modifications of active compounds were found to shift their inhibitory profiles toward kinases with different functions." @default.
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- W2312565798 date "2012-12-11" @default.
- W2312565798 modified "2023-10-16" @default.
- W2312565798 title "Assessing the Target Differentiation Potential of Imidazole-Based Protein Kinase Inhibitors" @default.
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- W2312565798 doi "https://doi.org/10.1021/jm3014508" @default.
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