Matches in SemOpenAlex for { <https://semopenalex.org/work/W2312569878> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2312569878 endingPage "1993" @default.
- W2312569878 startingPage "1987" @default.
- W2312569878 abstract "A series of N-[3-(5H-dibenzo[a, d]cyclohepten-5-ylidene)propyl]-N-methylamino- (6a) and N-[3-(6H-dibenz-[b, e]oxepin-11-ylidene)propyl]-N-methylamino-alkanoic acid derivatives (6b) and related compounds (6c-f) were synthesized and examined for pharmacological activities in vitro, i.e., inhibitory effect on monoamine [noradrenaline (NA) and 5-hydroxytryptamine (5-HT)] uptake, inhibitory effect on 5-HT-, histamine-, acetylcholine- and NA-induced contraction, and binding affinity for alpha 2-adrenoceptor and dopamine D2-receptor. In vitro tests indicated that zwitter-ionization was capable of maintaining H1-antihistaminic activity while greatly reducing other pharmacological activities. Further, 6a-f showed much stronger inhibitory effects on compound 48/80-induced lethality in rats than did the corresponding N,N-dimethylamines (2a-f). 3-[N-[3-(6H-Dibenz[b, e]oxepin-11-ylidene)propyl]-N-methylamino]- propionic acid (6b-2), selected as a candidate antiallergic agent of a new type, equally potent in rats and guinea-pigs, exhibited strong inhibitory effects on 48 h homologous passive cutaneous anaphylaxis (PCA) in rats (ED50 = 0.019 mg/kg, p.o.) and on histamine-induced bronchoconstriction in anesthetized guinea-pigs (ED50 = 0.0067 mg/kg, p.o.)." @default.
- W2312569878 created "2016-06-24" @default.
- W2312569878 creator A5028656684 @default.
- W2312569878 creator A5055165613 @default.
- W2312569878 creator A5057708246 @default.
- W2312569878 creator A5058545421 @default.
- W2312569878 creator A5073563511 @default.
- W2312569878 creator A5078105582 @default.
- W2312569878 creator A5083166651 @default.
- W2312569878 date "1993-01-01" @default.
- W2312569878 modified "2023-09-26" @default.
- W2312569878 title "Study on Zwitter-Ionization of Drugs. II. Synthesis and Pharmacological Activity of Some N-(3-(5H-Dibenzo(a, d)cyclohepten-5-ylidene)propyl)- N-methylamino- and N-(3-(6H-Dibenz(b,e)oxepin-11-ylidene)propyl)- N-methylamino-alkanoic Acid Derivatives and Related Compounds." @default.
- W2312569878 doi "https://doi.org/10.1248/cpb.41.1987" @default.
- W2312569878 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8293521" @default.
- W2312569878 hasPublicationYear "1993" @default.
- W2312569878 type Work @default.
- W2312569878 sameAs 2312569878 @default.
- W2312569878 citedByCount "7" @default.
- W2312569878 countsByYear W23125698782013 @default.
- W2312569878 countsByYear W23125698782022 @default.
- W2312569878 crossrefType "journal-article" @default.
- W2312569878 hasAuthorship W2312569878A5028656684 @default.
- W2312569878 hasAuthorship W2312569878A5055165613 @default.
- W2312569878 hasAuthorship W2312569878A5057708246 @default.
- W2312569878 hasAuthorship W2312569878A5058545421 @default.
- W2312569878 hasAuthorship W2312569878A5073563511 @default.
- W2312569878 hasAuthorship W2312569878A5078105582 @default.
- W2312569878 hasAuthorship W2312569878A5083166651 @default.
- W2312569878 hasBestOaLocation W23125698781 @default.
- W2312569878 hasConcept C1122143 @default.
- W2312569878 hasConcept C126322002 @default.
- W2312569878 hasConcept C170493617 @default.
- W2312569878 hasConcept C17077164 @default.
- W2312569878 hasConcept C185592680 @default.
- W2312569878 hasConcept C187714386 @default.
- W2312569878 hasConcept C202751555 @default.
- W2312569878 hasConcept C2775864247 @default.
- W2312569878 hasConcept C2775910092 @default.
- W2312569878 hasConcept C2776042228 @default.
- W2312569878 hasConcept C2776460385 @default.
- W2312569878 hasConcept C2778815084 @default.
- W2312569878 hasConcept C2780769369 @default.
- W2312569878 hasConcept C42533223 @default.
- W2312569878 hasConcept C55493867 @default.
- W2312569878 hasConcept C71240020 @default.
- W2312569878 hasConcept C71924100 @default.
- W2312569878 hasConcept C98274493 @default.
- W2312569878 hasConceptScore W2312569878C1122143 @default.
- W2312569878 hasConceptScore W2312569878C126322002 @default.
- W2312569878 hasConceptScore W2312569878C170493617 @default.
- W2312569878 hasConceptScore W2312569878C17077164 @default.
- W2312569878 hasConceptScore W2312569878C185592680 @default.
- W2312569878 hasConceptScore W2312569878C187714386 @default.
- W2312569878 hasConceptScore W2312569878C202751555 @default.
- W2312569878 hasConceptScore W2312569878C2775864247 @default.
- W2312569878 hasConceptScore W2312569878C2775910092 @default.
- W2312569878 hasConceptScore W2312569878C2776042228 @default.
- W2312569878 hasConceptScore W2312569878C2776460385 @default.
- W2312569878 hasConceptScore W2312569878C2778815084 @default.
- W2312569878 hasConceptScore W2312569878C2780769369 @default.
- W2312569878 hasConceptScore W2312569878C42533223 @default.
- W2312569878 hasConceptScore W2312569878C55493867 @default.
- W2312569878 hasConceptScore W2312569878C71240020 @default.
- W2312569878 hasConceptScore W2312569878C71924100 @default.
- W2312569878 hasConceptScore W2312569878C98274493 @default.
- W2312569878 hasIssue "11" @default.
- W2312569878 hasLocation W23125698781 @default.
- W2312569878 hasLocation W23125698782 @default.
- W2312569878 hasOpenAccess W2312569878 @default.
- W2312569878 hasPrimaryLocation W23125698781 @default.
- W2312569878 hasRelatedWork W1993726734 @default.
- W2312569878 hasRelatedWork W2001574005 @default.
- W2312569878 hasRelatedWork W2380551151 @default.
- W2312569878 hasRelatedWork W2413656934 @default.
- W2312569878 hasRelatedWork W2434193864 @default.
- W2312569878 hasRelatedWork W2439480214 @default.
- W2312569878 hasRelatedWork W2462491261 @default.
- W2312569878 hasRelatedWork W2517770843 @default.
- W2312569878 hasRelatedWork W4247606404 @default.
- W2312569878 hasRelatedWork W66110367 @default.
- W2312569878 hasVolume "41" @default.
- W2312569878 isParatext "false" @default.
- W2312569878 isRetracted "false" @default.
- W2312569878 magId "2312569878" @default.
- W2312569878 workType "article" @default.