Matches in SemOpenAlex for { <https://semopenalex.org/work/W2312587456> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W2312587456 abstract "PR-5 Background Overweight and obesity have been hypothesized to promote pancreatic carcinogenesis by increasing insulin and IGF-1 levels. These factors may stimulate cell division, promote tumor development and increase local blood flow. Studies have reported inconsistent results between overweight and obesity and pancreatic cancer risk. Methods A pooled analysis of the primary data from 14 prospective cohort studies was conducted. The study sample consisted of 786,042 men and women among whom 2,135 pancreatic cases were identified. All studies measured height and weight at baseline; weight in early adulthood was measured in 11 studies. Study-specific multivariate relative risks (MV RR) and 95% confidence intervals (CI) were calculated by Cox proportional hazards models, and then pooled by a random effects model. Results Compared to individuals with a BMI between 21-22.9 kg/m², a 16% (95% CI: 1-34%) and 47% (95% CI: 23-75%) higher pancreatic cancer risk was observed among overweight (BMI between 25-29.9 kg/m²) and obese (BMI≥30 kg/m²) individuals, respectively. Results were similar for men and women. A positive association was observed for BMI in early adulthood (pooled MV RR = 1.29, 95% CI= 1.07-1.55) comparing BMI≥25 kg/m² to a BMI between 21-22.9 kg/m². Pancreatic cancer risk was higher among individuals who were overweight in early adulthood (BMI≥25 kg/m²) and not obese at baseline (BMI Discussion and Conclusions Overall, positive associations were observed for overweight and obese individuals and pancreatic cancer risk. As pancreatic tumors are highly fatal, determining preventive factors offers a feasible approach to reducing this disease’s morbidity and mortality. These results are in line with The World Cancer Research Fund recommendation to maintain body weight within the normal range, as overweight and obesity are also linked to other cancers, diabetes and cardiovascular disease. Citation Information: Cancer Prev Res 2008;1(7 Suppl):PR-5." @default.
- W2312587456 created "2016-06-24" @default.
- W2312587456 creator A5000254686 @default.
- W2312587456 creator A5018554532 @default.
- W2312587456 date "2008-11-01" @default.
- W2312587456 modified "2023-09-25" @default.
- W2312587456 title "Abstract PR-5: A pooled analysis of 14 cohort studies of body mass index and pancreatic cancer risk" @default.
- W2312587456 doi "https://doi.org/10.1158/1940-6207.prev-08-pr-5" @default.
- W2312587456 hasPublicationYear "2008" @default.
- W2312587456 type Work @default.
- W2312587456 sameAs 2312587456 @default.
- W2312587456 citedByCount "0" @default.
- W2312587456 crossrefType "proceedings-article" @default.
- W2312587456 hasAuthorship W2312587456A5000254686 @default.
- W2312587456 hasAuthorship W2312587456A5018554532 @default.
- W2312587456 hasConcept C121608353 @default.
- W2312587456 hasConcept C126322002 @default.
- W2312587456 hasConcept C188816634 @default.
- W2312587456 hasConcept C201903717 @default.
- W2312587456 hasConcept C2780210213 @default.
- W2312587456 hasConcept C2780221984 @default.
- W2312587456 hasConcept C2780586474 @default.
- W2312587456 hasConcept C44249647 @default.
- W2312587456 hasConcept C50382708 @default.
- W2312587456 hasConcept C511355011 @default.
- W2312587456 hasConcept C71924100 @default.
- W2312587456 hasConcept C72563966 @default.
- W2312587456 hasConcept C82789193 @default.
- W2312587456 hasConceptScore W2312587456C121608353 @default.
- W2312587456 hasConceptScore W2312587456C126322002 @default.
- W2312587456 hasConceptScore W2312587456C188816634 @default.
- W2312587456 hasConceptScore W2312587456C201903717 @default.
- W2312587456 hasConceptScore W2312587456C2780210213 @default.
- W2312587456 hasConceptScore W2312587456C2780221984 @default.
- W2312587456 hasConceptScore W2312587456C2780586474 @default.
- W2312587456 hasConceptScore W2312587456C44249647 @default.
- W2312587456 hasConceptScore W2312587456C50382708 @default.
- W2312587456 hasConceptScore W2312587456C511355011 @default.
- W2312587456 hasConceptScore W2312587456C71924100 @default.
- W2312587456 hasConceptScore W2312587456C72563966 @default.
- W2312587456 hasConceptScore W2312587456C82789193 @default.
- W2312587456 hasLocation W23125874561 @default.
- W2312587456 hasOpenAccess W2312587456 @default.
- W2312587456 hasPrimaryLocation W23125874561 @default.
- W2312587456 hasRelatedWork W1992312182 @default.
- W2312587456 hasRelatedWork W2025011525 @default.
- W2312587456 hasRelatedWork W2086015270 @default.
- W2312587456 hasRelatedWork W2105524540 @default.
- W2312587456 hasRelatedWork W2136269559 @default.
- W2312587456 hasRelatedWork W2145554925 @default.
- W2312587456 hasRelatedWork W2271769099 @default.
- W2312587456 hasRelatedWork W2317846882 @default.
- W2312587456 hasRelatedWork W2329230168 @default.
- W2312587456 hasRelatedWork W2386551563 @default.
- W2312587456 hasRelatedWork W2409083264 @default.
- W2312587456 hasRelatedWork W2530529550 @default.
- W2312587456 hasRelatedWork W2547713098 @default.
- W2312587456 hasRelatedWork W2739213032 @default.
- W2312587456 hasRelatedWork W2774202458 @default.
- W2312587456 hasRelatedWork W2805034135 @default.
- W2312587456 hasRelatedWork W2954950889 @default.
- W2312587456 hasRelatedWork W2510594353 @default.
- W2312587456 hasRelatedWork W2610593317 @default.
- W2312587456 hasRelatedWork W2737214028 @default.
- W2312587456 isParatext "false" @default.
- W2312587456 isRetracted "false" @default.
- W2312587456 magId "2312587456" @default.
- W2312587456 workType "article" @default.