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- W2312589534 abstract "To determine whether women≥43 years of age demonstrate live birth potential with autologous in vitro fertilization (IVF) and whether such potential can be enhanced by having normal AMH levels. Retrospective analysis. All patients≥43 years of age who underwent IVF treatment between 1/2009 and 12/2011 with a documented AMH were included. Patients with severe male factor or an abnormal uterine cavity were excluded. The primary outcome was live birth rate. Secondary outcomes included cancellation rate, number of oocytes retrieved, mature oocytes, oocytes fertilized, implantation rate, and total pregnancy rate. Kruskal-Wallis and chi squared tests were used in analyses. P<0.05 was considered statistically significant. 191 patients undergoing 266 cycles of IVF met inclusion criteria. Results are shown in Table 1.Tabled 1Cycle Characteristics and OutcomesAMH<0.2AMH 0.2-0.79AMH 0.8-10P-valueN3916562Age44.19±1.2643.76±0.9543.61±0.79NSAMH0.14±0.04.38±.161.77±1.180.0001BMI23.37±3.1923.81±6.6425.14±5.14NSPrior attempts1.19±1.522.71±3.341.9±2.230.045% Cancelled43.5933.333.220.0001Oocytes retrieved3.50±1.855.92±3.8811.59±5.250.0001Mature2.86±1.644.55±3.079.56±4.570.00012PN2.27+1.523.17+2.367.19+3.740.0001Embryos per ET∗Embryo transfer (ET).2.32±1.293.22±1.594.29±1.490.0001Implantation rate1.32±5.744.79±13.452.84±10.39NSTotal pregnancies (%/cycle)2(5.13)25(15.15)14(22.58)0.008Clinical pregnancies (%/cycle)2(5.13)13(7.88)6(9.68)NSLive Birth/Ongoing (%/cycle)07(4.24)4(6.45)NS∗ Embryo transfer (ET). Open table in a new tab Patients≥43 years of age can still achieve live birth, albeit at a very low rate. While chronologically older patients with a normal AMH did have a better response to stimulation, were able to have more embryos transferred and had a higher total pregnancy rate, live birth rates were not significantly enhanced. Patients≥43 with undetectable AMH did not have a chance of delivery in this preliminary work." @default.
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- W2312589534 date "2012-09-01" @default.
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- W2312589534 title "Chances of pregnancy at extreme of age: does anti-mullerian hormone (AMH) matter?" @default.
- W2312589534 doi "https://doi.org/10.1016/j.fertnstert.2012.07.728" @default.
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