FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2312671608> ?p ?o ?g. }

• W2312671608 abstract "INTRODUCTION: Glioblastoma (GBM) is the most aggressive type of primary brain tumour. O6-methylguanine-DNA-methytransferase (MGMT) gene promoter methylation status has proven to be a predictive prognostic marker for longer survival in patients with newly diagnosed GBM treated with surgery, radiotherapy and chemotherapy. Patients showing a methylation of the MGMT promoter have a longer overall survival. We used Diffusion-Weighted Magnetic Resonance Imaging (DW-MRI) to obtain data about brain tumor structure. It is know that an increased perilesional swelling and tumor cellularity affect DW MRI and the Apparent Diffusion Coefficient (ADC). So far, few studies have analyzed the association between ADC values and MGMT methylation status with conflicting results. More trials are needed to assess the predictive value of DWI MRI as a non-invasive assessment of MGMT promoter methylation status that could add helpful information for clinical management. OBJECTIVE: To assess the correlation between ADC values and MGMT promoter methylation status in patients with GBM. MATERIAL AND METHODS: A retrospective analysis of 3 Tesla MR preoperative studies was perfomed in 13 patients with newly diagnosed GBM (7 M,6 F, mean age 60 years). The analysis of ADC value within the tumor was conducted using automatic co-registration between ADC maps and T1 contrast enhanced weighed images, with MathLab®-based SPM8® dedicated software, and semiautomatic quantitative analysis with 3D Slicer®. MGMT status was evaluated with polymerase chain reaction (PCR) real time (Pyromark Q96 ID System®) in the tumor tissue. RESULTS: The relationship between minimum ADC and percentage of MGMT methylation status was tested with Pearson's linear correlation coefficient, showing moderate correlation (r = 0,48). Observing the high variability of the minimum ADC data, the population has been divided into 4 classes, to reduce this problem. Plotted data revealed a strong correlation between minimum ADC plotted groups and MGMT(r = 0,94). Furthermore, minimum ADC values in tumors presenting under the threshold of 20% of MGMT methylation status were significantly different compared to minimum ACD values measured in tumors over 20% of MGMT methylation status (non parametric Mann-Whitney test, p = 0,04). DISCUSSION: DW-MRI may provide important insight into subtypes of GBM with different gene expressions. Recent studies found an association between the ADC values and the MGMT promoter methylation status. Our findings, even if limited by a relatively small population, showed that minimum ADC value measured within tumor was statistically different between GBM showing MGMT status methylation respectively below and above 20%. CONCLUSION: ADC values may be considered as a noninvasive biomarker of GBM MGMT promoter methylation status and furthermore as an index of patients prognosis." @default.
• W2312671608 created "2016-06-24" @default.
• W2312671608 creator A5005587302 @default.
• W2312671608 creator A5031523892 @default.
• W2312671608 creator A5034412938 @default.
• W2312671608 creator A5034586936 @default.
• W2312671608 creator A5043506911 @default.
• W2312671608 creator A5056036105 @default.
• W2312671608 creator A5067688250 @default.
• W2312671608 creator A5074501097 @default.
• W2312671608 creator A5078601003 @default.
• W2312671608 creator A5084180087 @default.
• W2312671608 date "2014-09-01" @default.
• W2312671608 modified "2023-09-28" @default.
• W2312671608 title "P16.26 * MINIMUM APPARENT DIFFUSION COEFFICIENT MEASUREDBY 3T MR IMAGES IN GLIOBLASTOMA AND O6-METHYLGUANINE-DNA-METHYTRANSFERASE GENE PROMOTER METHYLATED STATUS" @default.
• W2312671608 doi "https://doi.org/10.1093/neuonc/nou174.321" @default.
• W2312671608 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4185685" @default.
• W2312671608 hasPublicationYear "2014" @default.
• W2312671608 type Work @default.
• W2312671608 sameAs 2312671608 @default.
• W2312671608 citedByCount "0" @default.
• W2312671608 crossrefType "journal-article" @default.
• W2312671608 hasAuthorship W2312671608A5005587302 @default.
• W2312671608 hasAuthorship W2312671608A5031523892 @default.
• W2312671608 hasAuthorship W2312671608A5034412938 @default.
• W2312671608 hasAuthorship W2312671608A5034586936 @default.
• W2312671608 hasAuthorship W2312671608A5043506911 @default.
• W2312671608 hasAuthorship W2312671608A5056036105 @default.
• W2312671608 hasAuthorship W2312671608A5067688250 @default.
• W2312671608 hasAuthorship W2312671608A5074501097 @default.
• W2312671608 hasAuthorship W2312671608A5078601003 @default.
• W2312671608 hasAuthorship W2312671608A5084180087 @default.
• W2312671608 hasBestOaLocation W23126716081 @default.
• W2312671608 hasConcept C104317684 @default.
• W2312671608 hasConcept C126838900 @default.
• W2312671608 hasConcept C142724271 @default.
• W2312671608 hasConcept C143409427 @default.
• W2312671608 hasConcept C143998085 @default.
• W2312671608 hasConcept C150194340 @default.
• W2312671608 hasConcept C190727270 @default.
• W2312671608 hasConcept C2776194525 @default.
• W2312671608 hasConcept C2777389519 @default.
• W2312671608 hasConcept C2779527866 @default.
• W2312671608 hasConcept C2989005 @default.
• W2312671608 hasConcept C33288867 @default.
• W2312671608 hasConcept C502942594 @default.
• W2312671608 hasConcept C54355233 @default.
• W2312671608 hasConcept C70816921 @default.
• W2312671608 hasConcept C71924100 @default.
• W2312671608 hasConcept C86803240 @default.
• W2312671608 hasConcept C91965660 @default.
• W2312671608 hasConceptScore W2312671608C104317684 @default.
• W2312671608 hasConceptScore W2312671608C126838900 @default.
• W2312671608 hasConceptScore W2312671608C142724271 @default.
• W2312671608 hasConceptScore W2312671608C143409427 @default.
• W2312671608 hasConceptScore W2312671608C143998085 @default.
• W2312671608 hasConceptScore W2312671608C150194340 @default.
• W2312671608 hasConceptScore W2312671608C190727270 @default.
• W2312671608 hasConceptScore W2312671608C2776194525 @default.
• W2312671608 hasConceptScore W2312671608C2777389519 @default.
• W2312671608 hasConceptScore W2312671608C2779527866 @default.
• W2312671608 hasConceptScore W2312671608C2989005 @default.
• W2312671608 hasConceptScore W2312671608C33288867 @default.
• W2312671608 hasConceptScore W2312671608C502942594 @default.
• W2312671608 hasConceptScore W2312671608C54355233 @default.
• W2312671608 hasConceptScore W2312671608C70816921 @default.
• W2312671608 hasConceptScore W2312671608C71924100 @default.
• W2312671608 hasConceptScore W2312671608C86803240 @default.
• W2312671608 hasConceptScore W2312671608C91965660 @default.
• W2312671608 hasLocation W23126716081 @default.
• W2312671608 hasLocation W23126716082 @default.
• W2312671608 hasOpenAccess W2312671608 @default.
• W2312671608 hasPrimaryLocation W23126716081 @default.
• W2312671608 hasRelatedWork W149211460 @default.
• W2312671608 hasRelatedWork W2142279946 @default.
• W2312671608 hasRelatedWork W2329655639 @default.
• W2312671608 hasRelatedWork W2344198076 @default.
• W2312671608 hasRelatedWork W2417361172 @default.
• W2312671608 hasRelatedWork W2419481373 @default.
• W2312671608 hasRelatedWork W2488054337 @default.
• W2312671608 hasRelatedWork W2497919106 @default.
• W2312671608 hasRelatedWork W2565978524 @default.
• W2312671608 hasRelatedWork W2755791336 @default.
• W2312671608 hasRelatedWork W2851237286 @default.
• W2312671608 hasRelatedWork W2874304385 @default.
• W2312671608 hasRelatedWork W2980080276 @default.
• W2312671608 hasRelatedWork W3034855871 @default.
• W2312671608 hasRelatedWork W3039886107 @default.
• W2312671608 hasRelatedWork W3131137193 @default.
• W2312671608 hasRelatedWork W3135724915 @default.
• W2312671608 hasRelatedWork W3158164171 @default.
• W2312671608 hasRelatedWork W3158989562 @default.
• W2312671608 hasRelatedWork W3202082227 @default.
• W2312671608 isParatext "false" @default.
• W2312671608 isRetracted "false" @default.
• W2312671608 magId "2312671608" @default.
• W2312671608 workType "article" @default.