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- W2312690793 abstract "The antigenic heterogeneity of the reticular framework in the lymphoid tissues is well documented in mice and rats. In the present study, the reticular framework of the human lymphoid tissues was examined with special references to heterogeneity.Surgically resected human spleens, lymph nodes, and tonsils were investigated. Thymi were obtained from autopsy cases. Formalin-fixed materials were embedded in paraffin and serial sections were prepared for hematoxylin-eosin, silver staining, and immunohistochemical examination. Immunoelectron microscopy was also applied. The reticular framework of malignant lymphoma was also examined.The reticulum cells and reticulin fibers in the framework of the spleen, lymph node, tonsil and thymus were immunostained for type IV collagen, laminin and fibronectin. In the spleen, lymph node and tonsil, α-smooth muscle actin (α-SMA)-positive reticulum cells formed the reticular framework of the T-lymphocyte area and ensheathed the reticulan fibers. Interdigitating cells (IDCs) were scattered throughout the framework and some were attached to the reticulum cells. In the B-lymphocyte area, reticulum cells were α-SMA-negative. The reticulan fibers were involved in the mesh of the follicular dendritic cells (FDCs) in some areas and were covered by the cytoplasm of the FDCs. The reticular framework was heterogeneous in the T- and B-lymphocyte areas. In the thymus, reticulum cells were keratin-positive and their immunohistochemical character was different from those in the T-lymphocyte area of the peripheral lymphoid tissues. In the reticular framework of malignant lymphoma, reticulum cells/fibers showed positive reactivity for type IV collagen, laminin and fibronectin. The heterogeneity of the reticular framework was also found in the T- and B-lymphocyte areas of malignant lymphoma.The reticular framework is specialized into heterogeneous components in T- and B-lymphocyte areas and may play a role in the formation of the distinct microenvironment specific for lymphoid subclasses." @default.
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- W2312690793 date "1998-01-01" @default.
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- W2312690793 title "Heterogeneity of the reticular framework in the human lymphoid tissues." @default.
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- W2312690793 doi "https://doi.org/10.3960/jslrt1997.38.181" @default.
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