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- W2312750109 abstract "The effects of capsaicin on the drug-metabolizing systems were investigated in rat liver. Capsaicin (50mg/kg b. w., p. o.) produced no alteration of the appearance and body weight for a period of 14 days. The sleeping time induced by pentobarbital (50mg/kg b. w., i. p.), which is an index of the mixed function oxidase system activity, was prolonged in the rats given capsaicin. However, the cytochrome P-450 content and aniline hydroxylase and aminopyrine demethylase in vitro activities were almost unchanged in the rats treated with capsaicin. On the other hand, the activities of conjugation enzymes, UDP-glucuronyltransferase and glutathione S-transferase, were significantly reduced by the capsaicin treatment.These results suggest that capsaicin can increase the toxicity of many xenobiotics by decreasing both phase I and II reactions in drug metabolism." @default.
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- W2312750109 date "1989-01-01" @default.
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- W2312750109 title "Effects of Capsaicin on Drug-Metabolizing Enzymes in Rat Liver" @default.
- W2312750109 doi "https://doi.org/10.3358/shokueishi.30.548" @default.
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