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- W2312796694 abstract "Zinc is a component of one tenth of all human proteins. Its cellular concentration is tightly regulated because its dyshomeostasis has catastrophic health consequences. Two families of zinc transporters control zinc homeostasis in organisms, but there is little information about their specific developmental roles. We show that the ZIP transporter fear-of-intimacy (foi) is necessary for the formation of Drosophila muscles. In foi mutants, myoblasts segregate normally, but their specification is affected, leading to the formation of a misshapen muscle pattern and distorted midgut. The observed phenotypes could be ascribed to the inactivation of specific zing-finger transcription factors (ZFTFs), supporting the hypothesis that they a consequence of a zinc intracellular depletion. Accordingly, foi phenotypes can be rescued by mesodermal expression of other ZIP members with similar subcellular localization. We propose that Foi acts mostly as a transporter to regulate zinc intracellular homeostasis, thereby impacting on the activity of ZFTFs that control specific developmental processes. Our results additionally suggest a possible explanation for the presence of large numbers of zinc transporters in organisms based on differences in ion transport specificity and/or degrees of activity among transporters." @default.
- W2312796694 created "2016-06-24" @default.
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- W2312796694 date "2016-01-01" @default.
- W2312796694 modified "2023-09-28" @default.
- W2312796694 title "Fear-of-intimacy mediated zinc transport controls the function of Zn-finger transcription factors involved in myogenesis" @default.
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- W2312796694 doi "https://doi.org/10.1242/dev.131953" @default.
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