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- W2312797515 abstract "Drug-induced liver injury (DILI) continues to command attention across the spectrum of health care from the lay public, patients, and clinicians, to the basic scientists, pharmaceutical industry, and regulatory agencies. Drug-induced liver injury reports are increasing overall, and severe cases sporadically make headlines in the lay press. It remains a leading cause of acute liver failure in the United States and around the world. It continues to challenge pharmaceutical companies and regulatory agencies to find better ways to prevent and monitor at a time when trimming health care costs is a widespread mandate. At the clinical level, DILI can be a devastating iatrogenic event for the individual patient and an unforgettable challenge to the clinician. Basic research into mechanisms of injury and markers of risk is the best hope for curtailing this disease that is rare in incidence, yet vast in its effects that go well beyond the individual patient. Indeed, DILI is a concern for all of us who are both prescribers of medications and consumers of health care." @default.
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- W2312797515 date "2014-05-31" @default.
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- W2312797515 title "Slow but Steady Progress in a Field with Many Knowledge Gaps" @default.
- W2312797515 doi "https://doi.org/10.1055/s-0034-1375952" @default.
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