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- W2312810076 abstract "Background: Thrombotic thrombocytopenic purpura (TTP) is a clinically heterogeneous syndrome first described by Moschkowitz in 1924. Often postinfectious, but also autoimmune- or drug-associated, TTP is characterised by thrombocytopenia, Coombs-negative haemolytic anaemia, neurological deficits, renal impairment and fever. Inhibitory antibodies against von Willebrand factor (vWf)-cleaving protease lead to a functional deficiency of this protease and to unusually large multimers of vWf. These multimers are capable of agglutinating circulating platelets, thereby reducing platelet count and causing thrombotic microangiopathy concomitantly." @default.
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- W2312810076 date "2004-01-01" @default.
- W2312810076 modified "2023-10-18" @default.
- W2312810076 title "Moschcowitz syndrome mimicking basilar pathology" @default.
- W2312810076 doi "https://doi.org/10.1055/s-2004-833236" @default.
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